Pérez Camargo Dana A, Allende Pérez Silvia R, Rivera Franco Mónica M, Álvarez Licona Nelson E, Urbalejo Ceniceros Víctor I, Figueroa Baldenegro Lilian E
a Palliative Care Department , National Cancer Institute , Mexico City , Mexico.
b Postgraduate and Research Department , Medical Faculty, National Polytechnic Institute , Mexico City , Mexico.
Nutr Cancer. 2017 May-Jun;69(4):601-606. doi: 10.1080/01635581.2017.1299880. Epub 2017 Mar 29.
Patients with advanced cancer often experience symptoms of disease and treatment that contribute to distress such as weight loss, which is present in up to 85% of cancer patients. Palliative care in these patients focuses on care aimed at improving quality of life. Phase angle (PA) is obtained by bioelectric impedance analysis (BIA) and is associated with cellular function. It is considered a reliable marker of malnutrition. A low PA may suggest deterioration of the cell membrane, which in palliative patients may result in a short-term survival. The aim of this study was to associate PA and survival in palliative patients of the National Cancer Institute of Mexico. We included 452 patients (women, 56.4%); the average PA was 4.0°. The most frequent disease was gastric cancer (39.2%). Mean body mass index (BMI) was 22.84. The average survival of patients with PA ≤ 4° was 86 days, while in the group with PA > 4°, it was 163 days (P > 0.0001). PA showed significant positive correlation with survival time and BMI. Our results corroborate the reliability of PA in Mexican population, as an indicator of survival in palliative care patients compared to the reported literature in other countries.
晚期癌症患者常常会经历疾病和治疗带来的症状，这些症状会导致患者痛苦，比如体重减轻，高达85%的癌症患者都存在这一情况。对这些患者的姑息治疗侧重于旨在提高生活质量的护理。相位角（PA）通过生物电阻抗分析（BIA）获得，与细胞功能相关。它被认为是营养不良的可靠标志物。低PA可能提示细胞膜恶化，这在姑息治疗患者中可能导致短期生存。本研究的目的是探讨墨西哥国家癌症研究所姑息治疗患者的PA与生存情况之间的关联。我们纳入了452例患者（女性占56.4%）；平均PA为4.0°。最常见的疾病是胃癌（39.2%）。平均体重指数（BMI）为22.84。PA≤4°的患者平均生存期为86天，而PA>4°的患者组平均生存期为163天（P>0.0001）。PA与生存时间和BMI呈显著正相关。与其他国家报道的文献相比，我们的结果证实了PA在墨西哥人群中作为姑息治疗患者生存指标的可靠性。
