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In Vivo. 2022 May-Jun;36(3):1468-1476. doi: 10.21873/invivo.12853.
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Determination of serum bone-related minerals during denosumab treatment in osteoporosis patients with rheumatoid arthritis: Mineral change by denosumab in osteoporosis with rheumatoid arthritis.类风湿关节炎骨质疏松症患者地诺单抗治疗期间血清骨相关矿物质的测定：地诺单抗对类风湿关节炎合并骨质疏松症矿物质的影响
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Sarcopenia - Molecular mechanisms and open questions.肌肉减少症——分子机制与未解决的问题。
Ageing Res Rev. 2021 Jan;65:101200. doi: 10.1016/j.arr.2020.101200. Epub 2020 Oct 29.
2
Osteogenesis imperfecta-pathophysiology and therapeutic options.成骨不全症——病理生理学与治疗选择
Mol Cell Pediatr. 2020 Aug 14;7(1):9. doi: 10.1186/s40348-020-00101-9.
3
Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment.亚洲肌少症工作组：2019年肌少症诊断与治疗共识更新
J Am Med Dir Assoc. 2020 Mar;21(3):300-307.e2. doi: 10.1016/j.jamda.2019.12.012. Epub 2020 Feb 4.
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Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy.乳清蛋白分离物补充可改善正在接受化疗的营养不良的晚期癌症患者的身体成分、肌肉力量和治疗耐受性。
Cancer Med. 2019 Nov;8(16):6923-6932. doi: 10.1002/cam4.2517. Epub 2019 Sep 30.
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RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass.RANKL 抑制剂可改善肌肉力量和胰岛素敏感性，并恢复骨量。
J Clin Invest. 2019 May 23;129(8):3214-3223. doi: 10.1172/JCI125915.
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Body composition and phase angle as an indicator of nutritional status in children with juvenile idiopathic arthritis.身体成分和相位角作为幼年特发性关节炎患儿营养状况的指标。
Pediatr Rheumatol Online J. 2018 Dec 27;16(1):82. doi: 10.1186/s12969-018-0297-y.
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Sarcopenia: revised European consensus on definition and diagnosis.肌少症：定义和诊断的欧洲共识修订版。
Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169.
8
Extracellular Water to Total Body Water Ratio in Viral Liver Diseases: A Study Using Bioimpedance Analysis.应用生物电阻抗分析技术研究病毒性肝病患者细胞外液与总体液比值
Nutrients. 2018 Aug 12;10(8):1072. doi: 10.3390/nu10081072.
9
Association Between Standardized Phase Angle, Nutrition Status, and Clinical Outcomes in Surgical Cancer Patients.标准化相位角与手术癌症患者营养状况和临床结局的关系。
Nutr Clin Pract. 2019 Jun;34(3):381-386. doi: 10.1002/ncp.10110. Epub 2018 Jun 5.
10
Electrical Properties Assessed by Bioelectrical Impedance Spectroscopy as Biomarkers of Age-related Loss of Skeletal Muscle Quantity and Quality.通过生物电阻抗光谱法评估的电学特性作为与年龄相关的骨骼肌量和质丢失的生物标志物。
J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1180-1186. doi: 10.1093/gerona/glw225.

在类风湿关节炎或胶原病患者中，地诺单抗治疗后身体成分对改善股骨颈骨密度的临床重要性。

Clinical Importance of Body Composition in Improving Bone Mineral Density of Femoral Neck After Denosumab Therapy in Patients With Rheumatoid Arthritis or Collagen Diseases.

作者信息

Nakano Mai, Miyake Akimitsu, Egashira Ryuichiro, Takeuchi Mariko, Moriguchi Misaki, Tonari Satoko, Saito Hitomi, Nishikawa Hiroki, Matsui Kiyoshi, Hagihara Keisuke

机构信息

Department of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Division of Allergology and Rheumatology, Department of Diabetes Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Hyogo, Japan.

出版信息

In Vivo. 2022 May-Jun;36(3):1468-1476. doi: 10.21873/invivo.12853.

DOI:10.21873/invivo.12853
PMID:35478104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9087069/
Abstract

BACKGROUND/AIM: To investigate factors associated with increased bone mineral density (BMD) of the neck of femur in rheumatoid arthritis or collagen diseases receiving denosumab, focusing on body composition calculated by bioelectrical impedance analysis (n=90, 78 females).

PATIENTS AND METHODS

We defined Δfemur as BMD (12 months minus baseline), using dual-energy X-ray absorptiometry after denosumab therapy. Factors associated with Δfemur were retrospectively investigated.

RESULTS

Low skeletal muscle index (SMI) was observed in 6 males and 32 females. There was a significant difference in phase angle (PhA) of the left leg (LL) between the Δfemur ≥0 (n=70) and Δfemur <0 (n=20) groups (p=0.040) but not in SMI (p=0.310). Multiple regression analysis indicated that PhA of LL was significantly related to Δfemur (p=0.0398).

CONCLUSION

PhA appears to be a clinically significant indicator of improvement of Δfemur in patients receiving denosumab.

摘要

背景/目的：研究接受地诺单抗治疗的类风湿关节炎或胶原病患者股骨颈骨密度（BMD）增加的相关因素，重点关注通过生物电阻抗分析计算的身体成分（n = 90，78名女性）。

患者与方法

在接受地诺单抗治疗后，我们使用双能X线吸收法将Δ股骨定义为骨密度（12个月减去基线）。回顾性研究与Δ股骨相关的因素。

结果

在6名男性和32名女性中观察到骨骼肌指数（SMI）较低。Δ股骨≥0（n = 70）组和Δ股骨<0（n = 20）组之间左腿（LL）的相位角（PhA）存在显著差异（p = 0.040），但SMI无显著差异（p = 0.310）。多元回归分析表明，LL的PhA与Δ股骨显著相关（p = 0.0398）。

结论

PhA似乎是接受地诺单抗治疗患者Δ股骨改善的临床重要指标。