Woolf Seth M, Baum Carl R
*Fellow (Woolf), Section of Pediatric Emergency Medicine; and †Professor of Pediatrics and of Emergency Medicine (Baum), Yale School of Medicine, New Haven, CT.
Pediatr Emerg Care. 2017 Apr;33(4):271-275. doi: 10.1097/PEC.0000000000001090.
Intrathecal baclofen therapy, given via an implanted pump in the abdominal wall either as a continuous infusion or bolus dosing, has been used for more than 25 years to treat the spasticity and dystonia associated with various brain and spinal cord conditions. Pediatric clinicians occasionally encounter baclofen pumps, and in the pediatric setting, significant morbidity can arise from their use. This article presents the background, mechanism of action, uses, and complications of intrathecal baclofen therapy and discusses various management strategies should complications occur.
鞘内注射巴氯芬疗法，通过植入腹壁的泵以持续输注或大剂量给药的方式进行，已用于治疗与各种脑和脊髓疾病相关的痉挛和肌张力障碍超过25年。儿科临床医生偶尔会遇到巴氯芬泵，在儿科环境中，使用这些泵可能会引发严重的发病情况。本文介绍了鞘内注射巴氯芬疗法的背景、作用机制、用途和并发症，并讨论了并发症发生时的各种管理策略。
