家族性腺瘤性息肉病：对丝裂霉素C敏感性增加无证据。
Familial polyposis coli: no evidence for increased sensitivity to mitomycin C.
作者信息
Mazzullo H A, Attwood J, Delhanty J D
机构信息
Department of Genetics and Biometry, University College London.
出版信息
J Med Genet. 1988 Apr;25(4):233-7. doi: 10.1136/jmg.25.4.233.
Abstract
Spontaneous chromosome instability is well established for the dominantly inherited cancer prone condition, familial polyposis coli (FPC), but conflicting results have been obtained regarding sensitivity to mitomycin C (MMC). We have investigated cell survival in fibroblasts and the induction of sister chromatid exchanges and chromosome damage in lymphocytes and fibroblasts after MMC treatment. We can find no evidence for a differential response of FPC cells as measured by any of these parameters, although individual FPC fibroblast cultures did show an enhanced chromosomal response. Overall, the FPC mutation does not appear to result in defective DNA repair in response to MMC.
摘要
对于显性遗传的癌症易患病症——家族性结肠息肉病（FPC），自发染色体不稳定性已得到充分证实，但关于对丝裂霉素C（MMC）的敏感性，却得到了相互矛盾的结果。我们研究了MMC处理后成纤维细胞的细胞存活率以及淋巴细胞和成纤维细胞中姐妹染色单体交换和染色体损伤的诱导情况。尽管个别FPC成纤维细胞培养物确实显示出增强的染色体反应，但通过这些参数测量，我们找不到FPC细胞有差异反应的证据。总体而言，FPC突变似乎不会导致对MMC反应的DNA修复缺陷。
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