Wang Ting-Yi, Libardo M Daben J, Angeles-Boza Alfredo M, Pellois Jean-Philippe
Department of Biochemistry and Biophysics, Texas A&M University , College Station, Texas 77843, United States.
Department of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States.
ACS Chem Biol. 2017 May 19;12(5):1170-1182. doi: 10.1021/acschembio.7b00237. Epub 2017 Apr 10.
Cell delivery or cell killing processes often involve the crossing or disruption of cellular membranes. We review how, by modifying the composition and properties of membranes, membrane oxidation can be exploited to enhance the delivery of macromolecular cargoes into live human cells. We also describe how membrane oxidation can be utilized to achieve efficient killing of bacteria by antimicrobial peptides. Finally, we present recent evidence highlighting how membrane oxidation is intimately engaged in natural biological processes such as antigen delivery in dendritic cells and in the killing of bacteria by antimicrobial peptides. Overall, the insights that have been recently gained in this area should facilitate the development of more effective delivery technologies and antimicrobial therapeutic approaches.
细胞递送或细胞杀伤过程通常涉及细胞膜的穿越或破坏。我们综述了如何通过改变膜的组成和性质，利用膜氧化来增强大分子货物向活的人类细胞内的递送。我们还描述了如何利用膜氧化来实现抗菌肽对细菌的有效杀伤。最后，我们展示了最近的证据，突出了膜氧化如何密切参与自然生物过程，如树突状细胞中的抗原递送以及抗菌肽对细菌的杀伤。总体而言，该领域最近获得的见解应有助于开发更有效的递送技术和抗菌治疗方法。
