Salazar-Juárez Alberto, Barbosa-Méndez Susana, Merino-Reyes Paola, Matus-Ortega Maura, Hernández-Calderón Jorge A, Antón Benito
Laboratorio de Neurobiología Molecular y Neuroquímica de Adicciones, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.
Braz J Psychiatry. 2017 Jul-Sep;39(3):228-236. doi: 10.1590/1516-4446-2016-2058. Epub 2017 Mar 23.
: Sedation/somnolence are major side effects of pharmacotherapies for depression, and negatively affect long-term treatment compliance in depressed patients. Use of mirtazapine (MIR), an atypical antidepressant approved for the treatment of moderate to severe depression with comorbid anxiety disorders, is associated with significant sedation/somnolence, especially in short-term therapy. Nonetheless, studies with human subjects suggest that MIR-induced sedation is transient, especially when high and repeated doses are used. The purpose of this study was to explore the effects of acute and chronic administration of different doses of MIR on sedation in the rat.
: Assessment of sedation was carried out behaviorally using the rotarod, spontaneous locomotor activity, and fixed-bar tests.
: A 15-mg/kg dose of MIR induced sedative effects for up to 60 minutes, whereas 30 mg/kg or more produced sedation within minutes and only in the first few days of administration.
: These results suggest that 30 mg/kg is a safe, well-tolerated dose of MIR which generates only temporary sedative effects.
镇静/嗜睡是抑郁症药物治疗的主要副作用，对抑郁症患者的长期治疗依从性产生负面影响。米氮平（MIR）是一种被批准用于治疗伴有共病焦虑症的中度至重度抑郁症的非典型抗抑郁药，使用该药与显著的镇静/嗜睡有关，尤其是在短期治疗中。尽管如此，人体研究表明，米氮平引起的镇静是短暂的，尤其是当使用高剂量且重复给药时。本研究的目的是探讨不同剂量米氮平急性和慢性给药对大鼠镇静作用的影响。
使用转棒试验、自发运动活动和固定杆试验对镇静作用进行行为学评估。
15mg/kg剂量的米氮平诱导的镇静作用可持续长达60分钟，而30mg/kg或更高剂量在给药后数分钟内即可产生镇静作用，且仅在给药的最初几天出现。
这些结果表明，30mg/kg是米氮平的一个安全、耐受性良好的剂量，只会产生暂时的镇静作用。
