Terena Stella Maris Lins, Fernandes Kristianne Porta Santos, Bussadori Sandra Kalill, Deana Alessandro Melo, Mesquita-Ferrari Raquel Agnelli
Doctoral Student in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (Uninove), São Paulo, SP, Brazil.
Full Professor, Rehabilitation Sciences and Biophotonics Applied to Health Sciences, Uninove, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2017 Feb;63(2):164-172. doi: 10.1590/1806-9282.63.02.164.
: The aim was to evaluate the effectiveness of the experimental synergists muscle ablation model to promote muscle hypertrophy, determine the period of greatest hypertrophy and its influence on muscle fiber types and determine differences in bilateral and unilateral removal to reduce the number of animals used in this model.
: Following the application of the eligibility criteria for the mechanical overload of the plantar muscle in rats, nineteen papers were included in the review.
: The results reveal a greatest hypertrophy occurring between days 12 and 15, and based on the findings, synergist muscle ablation is an efficient model for achieving rapid hypertrophy and the contralateral limb can be used as there was no difference between unilateral and bilateral surgery, which reduces the number of animals used in this model.
: This model differs from other overload models (exercise and training) regarding the characteristics involved in the hypertrophy process (acute) and result in a chronic muscle adaptation with selective regulation and modification of fast-twitch fibers in skeletal muscle. This is an efficient and rapid model for compensatory hypertrophy.
评估实验性协同肌切除模型促进肌肉肥大的有效性，确定最大肥大期及其对肌纤维类型的影响，并确定双侧和单侧切除的差异，以减少该模型中使用的动物数量。
在应用大鼠足底肌肉机械过载的纳入标准后，19篇论文被纳入综述。
结果显示最大肥大发生在第12天至15天之间，基于这些发现，协同肌切除是实现快速肥大的有效模型，并且由于单侧和双侧手术之间没有差异，对侧肢体可被使用，这减少了该模型中使用的动物数量。
该模型在肥大过程（急性）所涉及的特征方面与其他过载模型（运动和训练）不同，并导致骨骼肌中快肌纤维的选择性调节和改变的慢性肌肉适应。这是一个用于代偿性肥大的高效快速模型。
