Carvalho Renata Reis, Donadel Camila Dermínio, Cortez Arthur Fernandes, Valviesse Vitor Ribeiro Gomes de Almeida, Vianna Pedro Felipe de Almeida, Corrêa Bruno Bordallo
Hospital Universitário Gaffrée e Guinle, Brazil.
J Bras Nefrol. 2017 Mar;39(1):79-81. doi: 10.5935/0101-2800.20170013.
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the inability of antidiuretic hormone (ADH) suppression, compromising the mechanisms of water excretion and urinary concentration. It manifests as hyponatremia and its symptoms, especially neurological. There are many causes that trigger such disease, notably: central nervous system disorders, malignant neoplasm, drugs and others.
A 65 years female hypertensive patient presented clinical and laboratory manifestations of hyponatremia due to SIADH. It happened twice under use of herbal medication for osteoarthritis treatment.
The drug-related hyponatremia can be triggered by direct effect of the drug or by association with SIADH. The clinical manifestations presented could have been related to psychiatric condition and may have severe outcome if not properly diagnosed. The association of an herbal medicine to SIADH could be confirmed after a new episode of hyponatremia related to Harpagophytum procumbers reintroduction. Our literature review did not find this herbal medicine associated with SIADH, so far.
SIADH may be caused by herbal medicine described from now on their association in the literature.
抗利尿激素分泌不当综合征（SIADH）是指抗利尿激素（ADH）无法被抑制，影响了水排泄和尿液浓缩机制。其表现为低钠血症及其症状，尤其是神经系统症状。引发该疾病的原因众多，主要包括：中枢神经系统疾病、恶性肿瘤、药物等。
一名65岁的女性高血压患者出现了因SIADH导致的低钠血症的临床和实验室表现。在使用草药治疗骨关节炎期间发生了两次。
药物相关性低钠血症可由药物的直接作用或与SIADH相关联引发。所呈现的临床表现可能与精神状况有关，若未得到正确诊断可能会产生严重后果。在与刺果番荔枝重新引入相关的低钠血症新发作后，可确认草药与SIADH的关联。目前我们的文献综述尚未发现该草药与SIADH有关。
从现在起，文献中所述的草药可能会导致SIADH。
