恶性和良性卵巢肿瘤中的前列腺素和环核苷酸

Prostanoids and cyclic nucleotides in malignant and benign ovarian tumors.

作者信息

Heinonen P K, Metsä-Ketelä T

机构信息

Department of Obstetrics and Gynecology, University Central Hospital, Tampere, Finland.

出版信息

Med Oncol Tumor Pharmacother. 1988;5(1):11-5. doi: 10.1007/BF03003177.

DOI:10.1007/BF03003177

PMID:2835560

Abstract

The concentrations of prostaglandin E2 (PGE2), 6-keto-PGF1 alpha, thromboxane B2(TxB2), cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in ovarian tumor tissue were measured in 38 post-menopausal women with malignant or benign ovarian tumor and in six women without ovarian neoplasm. PGE2 and TxB2 contents in ovarian cancer tissue were significantly (P less than 0.05) higher than in normal ovarian tissue. The prostanoids were also increased in the cyst fluid of epithelial malignant tumors compared to cyst fluids of benign ovarian tumors. Cyclic AMP concentrations in cancer tissue were lower than in non-malignant ovarian tissue, while the levels of cGMP were similar in all groups studied.

摘要

在38名患有恶性或良性卵巢肿瘤的绝经后女性以及6名无卵巢肿瘤的女性中，测量了卵巢肿瘤组织中前列腺素E2（PGE2）、6-酮-前列腺素F1α、血栓素B2（TxB2）、环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的浓度。卵巢癌组织中的PGE2和TxB2含量显著高于正常卵巢组织（P<0.05）。与良性卵巢肿瘤的囊液相比，上皮性恶性肿瘤囊液中的类前列腺素也有所增加。癌组织中的环磷酸腺苷浓度低于非恶性卵巢组织，而在所有研究组中，环磷酸鸟苷水平相似。