海菖蒲素D：一种从海菖蒲中分离得到的新型黄酮O-葡萄糖苷硫酸盐
Thalassiolin D: a new flavone O-glucoside Sulphate from the seagrass Thalassia hemprichii.
作者信息
Hawas Usama W, Abou El-Kassem Lamia T
机构信息
a Faculty of Marine Sciences, Marine Chemistry Department , King Abdulaziz University , Jeddah , Saudi Arabia.
b Phytochemistry and Plant Systematic Department , National Research Centre , Cairo , Egypt.
出版信息
Nat Prod Res. 2017 Oct;31(20):2369-2374. doi: 10.1080/14786419.2017.1308367. Epub 2017 Mar 29.
Thalassiolin D, a new flavone O-glucoside sulphate along with three flavonoids, two steroids, p-hydroxybenzoic acid, 4,4'-dihydroxybenzophenone and nitrogen compound, octopamine were isolated from the seagrass Thalassia hemprichii, collected from the Saudi Red Sea coast. By extensive spectroscopic analysis including 1D and 2D NMR and MS data, the structure of the new compound was elucidated as diosmetin 7-O-β-glucosyl-2″-sulphate. The new compound displayed moderately in vitro antiviral HCV protease activity with IC value 16 μM.
从沙特红海海岸采集的海草泰来草中分离出了一种新的黄酮 O-葡萄糖苷硫酸盐——海草黄素 D，以及三种黄酮类化合物、两种甾体、对羟基苯甲酸、4,4'-二羟基二苯甲酮和含氮化合物章鱼胺。通过包括一维和二维核磁共振以及质谱数据在内的广泛光谱分析，确定了该新化合物的结构为香叶木素 7-O-β-葡萄糖基-2″-硫酸盐。该新化合物在体外对丙型肝炎病毒蛋白酶表现出中等活性，半数抑制浓度值为 16 μM。
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