来自钝叶豆瓣绿的C-糖基黄酮。

C-glycosyl flavones from Peperomia blanda.

作者信息

Velozo Leosvaldo S M, Ferreira Marcelo J P, Santos Maria Isabel S, Moreira Davyson L, Guimarães Elsie F, Emerenciano Vicente P, Kaplan Maria Auxiliadora C

机构信息

Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, Brazil.

出版信息

Fitoterapia. 2009 Mar;80(2):119-22. doi: 10.1016/j.fitote.2008.11.005. Epub 2008 Nov 30.

DOI:10.1016/j.fitote.2008.11.005

PMID:19100817

Abstract

The methanol extract from aerial parts of the Peperomia blanda (Piperaceae) yielded two C-glycosyl-flavones. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR, chemical transformation and comparison with the related known compounds. The structure of the new flavonoids were established as 4'-methoxy-vitexin 7-O-beta-D-xylopyranoside (1) (7-O-beta-D-xylopyranosyl-8-C-beta-D-glucopyranosyl-4'-methoxy-apigenin) and vicenin-2 (2). The antioxidant activity of both compounds was investigated using the DPPH assay. Both compounds showed only modest activity, with IC50 values of 357.2 microM for 1, and 90.5 microM for 2.

摘要

豆瓣绿（胡椒科）地上部分的甲醇提取物产生了两种C-糖基黄酮。基于广泛的光谱分析，包括一维和二维核磁共振、化学转化以及与相关已知化合物的比较，阐明了它们的结构。新黄酮类化合物的结构确定为4'-甲氧基牡荆素7-O-β-D-吡喃木糖苷（1）（7-O-β-D-吡喃木糖基-8-C-β-D-吡喃葡萄糖基-4'-甲氧基芹菜素）和异荭草苷（2）。使用DPPH法研究了这两种化合物的抗氧化活性。两种化合物仅表现出适度的活性，化合物1的IC50值为357.2微摩尔，化合物2的IC50值为90.5微摩尔。