心脏再生：只有工作，没有修复？

Cardiac regeneration: All work and no repair?

机构信息

National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.

Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.

出版信息

Sci Transl Med. 2017 Mar 29;9(383). doi: 10.1126/scitranslmed.aad9019.

DOI:10.1126/scitranslmed.aad9019

PMID:28356512

Abstract

Structural changes in the developing heart may influence the limited regenerative capacity of the adult heart. We examine how the workload exerted on the adult mammalian heart may limit regenerative capability and discuss recent therapies that demonstrate beneficial effects through unloading the heart.

摘要

心脏发育过程中的结构变化可能会影响成年心脏的有限再生能力。我们研究了成年哺乳动物心脏承受的工作量如何限制其再生能力，并讨论了最近通过减轻心脏负荷显示出有益效果的治疗方法。