Tamman Cardiovascular Research Institute, Sheba Medical Center, Tel Hashomer, Israel; Neufeld Cardiac Research Institute, Tel-Aviv University, Sheba Medical Center, Tel Hashomer, Israel; Sheba Center for Regenerative Medicine, Stem Cell, and Tissue Engineering, Tel Hashomer, Israel.
Tamman Cardiovascular Research Institute, Sheba Medical Center, Tel Hashomer, Israel; Neufeld Cardiac Research Institute, Tel-Aviv University, Sheba Medical Center, Tel Hashomer, Israel; Sheba Center for Regenerative Medicine, Stem Cell, and Tissue Engineering, Tel Hashomer, Israel.
Semin Cell Dev Biol. 2016 Oct;58:26-33. doi: 10.1016/j.semcdb.2016.04.012. Epub 2016 Apr 23.
One of the most ambitious goals in modern cardiology is to regenerate the injured myocardium. The human myocardium has poor regenerative power. Thus, significant myocardial injury results in irreversible damage, scar formation, remodeling, and dysfunction. The search for therapies that will improve myocardial regeneration needs a better understanding of the mechanisms of repair and regeneration. While the role of macrophages in inflammation, scar formation, and fibrosis are well defined, their role in myocardial regeneration is less clear. Recent reports have suggested that cardiac macrophages regulate myocardial regeneration in neonatal mice. The present review aims to describe the latest discoveries about the possible role of macrophages in myocardial regeneration. We discuss the promises and difficulties to translate the latest findings into new therapies.
在现代心脏病学中，最具雄心的目标之一是再生受损的心肌。人类心肌的再生能力很差。因此，大量的心肌损伤会导致不可逆转的损伤、瘢痕形成、重塑和功能障碍。为了寻找改善心肌再生的治疗方法，我们需要更好地了解修复和再生的机制。虽然巨噬细胞在炎症、瘢痕形成和纤维化中的作用已经得到很好的定义，但它们在心肌再生中的作用尚不清楚。最近的报道表明，心脏巨噬细胞调节新生小鼠的心肌再生。本综述旨在描述巨噬细胞在心肌再生中可能作用的最新发现。我们讨论了将最新发现转化为新疗法的前景和困难。
