柠檬酸杆菌：一种用于理解 3 型免疫先天和适应性成分相互作用的模式肠道病原体。
Citrobacter rodentium: a model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunity.
机构信息
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Mucosal Immunol. 2017 Sep;10(5):1108-1117. doi: 10.1038/mi.2017.47. Epub 2017 Jun 14.
Abstract
Citrobacter rodentium is a natural murine intestinal pathogen that shares a core set of virulence factors with the related human pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). C. rodentium is now the most widely used small animal model for studying the molecular underpinnings of EPEC and EHEC infections in vivo, including: enterocyte attachment; virulence; colonization resistance; and mucosal immunity. In this review, we discuss type 3 immunity in the context of C. rodentium infection and discuss recent publications that use this model to understand how the innate and adaptive components of immunity intersect to mediate host protection against enteric pathogens and maintain homeostasis with the microbiota.
摘要
柠檬酸杆菌是一种天然的鼠类肠道病原体，与相关的人类病原体肠致病性大肠杆菌（EPEC）和肠出血性大肠杆菌（EHEC）共享一组核心毒力因子。柠檬酸杆菌现在是研究 EPEC 和 EHEC 感染体内分子基础的最广泛使用的小动物模型，包括：肠细胞附着；毒力；定植抗性；和粘膜免疫。在这篇综述中，我们讨论了柠檬酸杆菌感染背景下的 3 型免疫，并讨论了最近使用该模型来了解先天和适应性免疫成分如何相互作用，从而介导宿主对肠道病原体的保护并与微生物组保持平衡的出版物。
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