发育与分化过程中的蛋白激酶CK2
Protein kinase CK2 in development and differentiation.
作者信息
Götz Claudia, Montenarh Mathias
机构信息
Department of Medical Biochemistry and Molecular Biology, Saarland University, D-66424 Homburg, Germany.
出版信息
Biomed Rep. 2017 Feb;6(2):127-133. doi: 10.3892/br.2016.829. Epub 2016 Dec 19.
Abstract
Among the human kinomes, protein kinase CK2 (formerly termed casein kinase II) is considered to be essential, as it is implicated in the regulation of various cellular processes. Experiments with pharmacological inhibitors of the kinase activity of CK2 provide evidence that CK2 is essential for development and differentiation. Therefore, the present review addresses the role of CK2 during embryogenesis, neuronal, adipogenic, osteogenic and myogenic differentiation in established model cell lines, and in embryonic, neural and mesenchymal stem cells. CK2 kinase activity appears to be essential in the early stages of differentiation, as CK2 inhibition at early time points generally prevents differentiation. In addition, the present review reports on target proteins of CK2 in embryogenesis and differentiation.
摘要
在人类激酶组中，蛋白激酶CK2（以前称为酪蛋白激酶II）被认为是必不可少的，因为它参与多种细胞过程的调节。使用CK2激酶活性的药理抑制剂进行的实验表明，CK2对发育和分化至关重要。因此，本综述探讨了CK2在胚胎发生、已建立的模型细胞系中的神经元、脂肪生成、成骨和肌源性分化以及胚胎、神经和间充质干细胞中的作用。CK2激酶活性在分化的早期阶段似乎至关重要，因为在早期时间点抑制CK2通常会阻止分化。此外，本综述还报道了CK2在胚胎发生和分化中的靶蛋白。
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