Menezes Regina, Tenreiro Sandra, Macedo Diana, Santos Cláudia N, Outeiro Tiago F
Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras 2781-901, Portugal. ; Instituto de Tecnologia Química e Biológica António Xavier, Av. da República, 2780-157 Oeiras, Universidade Nova de Lisboa, Portugal.
Instituto de Medicina Molecular, Av. Prof. Egas Moniz, Lisboa 1649-028, Portugal. ; CEDOC - Chronic Diseases Research Center, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, Lisboa 1169-056, Portugal.
Microb Cell. 2015 Jul 27;2(8):262-279. doi: 10.15698/mic2015.08.219.
The baker's yeast has been extensively explored for our understanding of fundamental cell biology processes highly conserved in the eukaryotic kingdom. In this context, they have proven invaluable in the study of complex mechanisms such as those involved in a variety of human disorders. Here, we first provide a brief historical perspective on the emergence of yeast as an experimental model and on how the field evolved to exploit the potential of the model for tackling the intricacies of various human diseases. In particular, we focus on existing yeast models of the molecular underpinnings of Parkinson's disease (PD), focusing primarily on the central role of protein quality control systems. Finally, we compile and discuss the major discoveries derived from these studies, highlighting their far-reaching impact on the elucidation of PD-associated mechanisms as well as in the identification of candidate therapeutic targets and compounds with therapeutic potential.
面包酵母已被广泛用于帮助我们理解在真核生物界高度保守的基本细胞生物学过程。在此背景下，事实证明它们在研究诸如涉及多种人类疾病的复杂机制方面具有不可估量的价值。在这里，我们首先简要介绍一下酵母作为实验模型的出现历程，以及该领域如何发展以利用该模型的潜力来应对各种人类疾病的复杂性。特别是，我们专注于帕金森病（PD）分子基础的现有酵母模型，主要关注蛋白质质量控制系统的核心作用。最后，我们汇总并讨论了这些研究的主要发现，强调了它们对阐明与PD相关的机制以及识别具有治疗潜力的候选治疗靶点和化合物的深远影响。
