Chen Chang-Lin, Huang Wei-Ling, Rapoport Alexander, Daugelavičius Rimantas, Chang Chuang-Rung
Institute of Biotechnology, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu City, 300044, Taiwan.
Current address: Facility Division, National Synchrotron Radiation Research Center, 101, Hsin-Ann Road, Hsinchu City, 300092, Taiwan.
Microb Cell. 2025 Aug 27;12:242-254. doi: 10.15698/mic2025.08.859. eCollection 2025.
Mitochondria are essential organelles that form a dynamic network within cells. The fusion, fission, and transport processes among mitochondria must reach a balance, which is achieved through complex regulatory mechanisms. These dynamic processes and regulatory pathways are highly conserved across species and are coordinated to help cells respond to environmental stress. The budding yeast has become an important model organism for studying mitochondria dynamics due to its genetic tractability and the conservation of key mitochondrial regulators. Previous research on mitochondria dynamics in yeast has provided valuable insights into the regulatory pathways in eukaryotic cells. It has helped to elucidate the mechanisms related to diseases associated with disrupted mitochondria dynamics. This review explores the molecular mechanisms underlying mitochondria dynamics and their physiological roles in . The knowledge we learned from the primary eukaryotic yeast cell will aid us in advancing future research on the regulatory mechanisms of mitochondria in both health and disease.
线粒体是细胞内形成动态网络的重要细胞器。线粒体之间的融合、裂变和运输过程必须达到平衡，这是通过复杂的调节机制实现的。这些动态过程和调节途径在物种间高度保守，并相互协调以帮助细胞应对环境压力。由于其遗传易处理性和关键线粒体调节因子的保守性，芽殖酵母已成为研究线粒体动态的重要模式生物。先前对酵母中线粒体动态的研究为真核细胞中的调节途径提供了有价值的见解。它有助于阐明与线粒体动态破坏相关疾病的机制。本综述探讨了线粒体动态背后的分子机制及其在……中的生理作用。我们从原始真核酵母细胞中学到的知识将有助于推动我们未来对健康和疾病状态下线粒体调节机制的研究。
