Shi Zumin, Zhen Shiqi, Orsini Nicola, Zhou Yonglin, Zhou Yijing, Liu Jianghong, Taylor Anne W
Department of Nutrition and Foodborne Disease Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.
Discipline of Medicine, University of Adelaide, L7 SAHMRI, North Terrace, Adelaide, 5000, Australia.
Environ Sci Pollut Res Int. 2017 May;24(13):12273-12280. doi: 10.1007/s11356-017-8871-2. Epub 2017 Mar 29.
Blood lead level is associated with increased risk of mortality, but dietary lead exposure and mortality, particularly with cancer, has not been studied in the general population. The objective of the study was to assess the association between lead intake and 10-year mortality among 2832 Chinese adults. Food intake was measured by 3-day weighed food record in 2002. We documented 184 deaths (63 cancer deaths and 70 cardiovascular disease (CVD) deaths) during 27,742 person-years of follow-up. Dietary lead intake was positively associated with cancer and all-cause mortality. Across quartiles of lead intake, hazard ratios (HRs) for cancer mortality were 1.00, 0.80 (0.33-1.92), 1.52 (0.65-3.56), and 3.00 (1.06-8.44) (p for trend 0.028). HRs for all-cause mortality were 1.00, 1.28 (0.83-1.98), 1.24 (0.78-1.97), and 2.24 (1.28-3.94) (p for trend 0.011). Each 30 μg/day increase of lead intake was associated with 25% (95% CI 3-52%) increase of all-cause mortality. There was an interaction between lead intake and hypertension in relation to CVD mortality (p for interaction 0.003): HRs conferred by every 30 μg/day of lead intake were 1.57 (0.98-2.52) and 1.06 (0.81-1.39) among those with or without hypertension. Dietary lead intake was positively related to cancer and all-cause mortality.
血铅水平与死亡风险增加相关，但在普通人群中，膳食铅暴露与死亡率，尤其是与癌症死亡率之间的关系尚未得到研究。本研究的目的是评估2832名中国成年人铅摄入量与10年死亡率之间的关联。2002年通过3天食物称重记录来测量食物摄入量。在27742人年的随访期间，我们记录了184例死亡（63例癌症死亡和70例心血管疾病（CVD）死亡）。膳食铅摄入量与癌症和全因死亡率呈正相关。在铅摄入量的四分位数中，癌症死亡率的风险比（HRs）分别为1.00、0.80（0.33 - 1.92）、1.52（0.65 - 3.56）和3.00（1.06 - 8.44）（趋势p值为0.028）。全因死亡率的HRs分别为1.00、1.28（0.83 - 1.98）、1.24（0.78 - 1.97）和2.24（1.28 - 3.94）（趋势p值为0.011）。铅摄入量每增加30μg/天，全因死亡率增加25%（95%CI为3% - 52%）。在CVD死亡率方面，铅摄入量与高血压之间存在交互作用（交互作用p值为0.003）：在有或没有高血压的人群中，铅摄入量每增加30μg/天的HRs分别为1.57（0.98 - 2.52）和1.06（0.81 - 1.39）。膳食铅摄入量与癌症和全因死亡率呈正相关。
