Department of Public Health Science, Graduate School, Korea University, Seoul 02841, Korea.
Interdisciplinary Program in Precision Public Health, Korea University, Seoul 02841, Korea.
Int J Environ Res Public Health. 2020 Sep 21;17(18):6898. doi: 10.3390/ijerph17186898.
Previous studies have consistently reported an increase in mortality risk, even at low levels of blood lead. The average blood lead concentration in the Korean population has steadily decreased but is still higher than that of developed countries. The purpose of this study was to examine the associations between mortality and blood lead concentrations for adults in Korea. We used the Korea National Health and Nutrition Examination Survey (2008-2013) linked Cause of Death data, which are followed by 2018. A total of 7308 subjects who aged over 30 at the baseline examination were included in the analyses. Cox proportional hazard model was used to estimate the hazard ratios of mortality from non-accidental causes and cancer mortality. The estimated hazard ratios (95% CI) for comparison of the second and third tertile group with the lowest tertile group were 2.01 (1.20, 3.40) and 1.91 (1.13, 3.23) for non-accidental mortality and 3.42 (95% CI: 1.65, 7.08) and 2.27 (95% CI: 1.09, 4.70) for cancer mortality, respectively. The dose-response relationship also showed significant increase in the risk of mortality at blood lead level between 1.5 and 6.0 μg/dL. Our findings suggest that potent policies to lower lead exposure are required for the general Korean population.
先前的研究一致报告称，即使血液铅水平较低，死亡率风险也会增加。韩国人口的平均血液铅浓度稳步下降，但仍高于发达国家。本研究旨在探讨韩国成年人死亡率与血液铅浓度之间的关系。我们使用了韩国国家健康和营养检查调查（2008-2013 年）与死亡原因数据相关联，该数据一直持续到 2018 年。共有 7308 名在基线检查时年龄超过 30 岁的受试者纳入了分析。使用 Cox 比例风险模型估计非意外原因和癌症死亡率的死亡率风险比。与最低三分位组相比，第二和第三三分位组的估计风险比（95%CI）分别为非意外死亡率的 2.01（1.20，3.40）和 1.91（1.13，3.23），癌症死亡率的 3.42（95%CI：1.65，7.08）和 2.27（95%CI：1.09，4.70）。剂量反应关系也表明，血液铅水平在 1.5 至 6.0μg/dL 之间，死亡率风险显著增加。我们的研究结果表明，需要针对韩国普通人群采取强有力的降低铅暴露政策。
