中华青牛胆茎中的克罗烷二萜糖苷
Clerodane Diterpenoid Glucosides from the Stems of Tinospora sinensis.
作者信息
Jiang Huan, Zhang Gui-Jie, Liu Yan-Fei, Wang Heng-Shan, Liang Dong
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin 541004, People's Republic of China.
College of Pharmacy, Guilin Medical University , Guilin 541004, People's Republic of China.
出版信息
J Nat Prod. 2017 Apr 28;80(4):975-982. doi: 10.1021/acs.jnatprod.6b00976. Epub 2017 Mar 30.
Ten new clerodane diterpenoid glucosides (1-10) and three known analogues (11-13) were isolated from an EtOAc extract of the stems of Tinospora sinensis. Spectroscopic analyses and chemical methods were used to elucidate the structures of these isolates. The absolute configurations of tinosinenosides A-C (1-3) were established by using experimental and calculated ECD data. Their cytotoxicity against the human epithelioid cervical carcinoma (HeLa) cell line and the nitric oxide production inhibitory activity of lipopolysaccharide-activated N9 microglial cells were tested. 1-Deacetyltinosposide A (12) exhibited mild cytotoxicity against HeLa cells, with an IC value of 8.35 ± 0.60 μM.
从中华青牛胆茎的乙酸乙酯提取物中分离出10个新的克罗烷二萜糖苷（1-10）和3个已知类似物（11-13）。采用光谱分析和化学方法阐明这些分离物的结构。通过实验和计算的电子圆二色谱（ECD）数据确定了中华青牛胆苷A-C（1-3）的绝对构型。测试了它们对人上皮样宫颈癌（HeLa）细胞系的细胞毒性以及脂多糖激活的N9小胶质细胞的一氧化氮产生抑制活性。1-去乙酰中华青牛胆苷A（12）对HeLa细胞表现出轻度细胞毒性，IC值为8.35±0.60μM。
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