Yıldırım Yusuf, Olcucu Onur, Gunaydin Zehra Karaagac, Ağca Alper, Ozgurhan Engin Bilge, Alagoz Cengiz, Mutaf Cagri, Demirok Ahmet
a Beyoglu Eye Research and Education Hospital, Department of Ophthalmology , Istanbul Turkey.
b Kirklareli Government Hospital , Kirklareli , Turkey.
Curr Eye Res. 2017 Jul;42(7):971-975. doi: 10.1080/02713683.2017.1284241. Epub 2017 Mar 30.
To compare the results of different protocols for accelerated corneal collagen cross-linking (CXL) in patients with progressive keratoconus.
This prospective comparative study involved 40 patients treated with intended UV-A radiance of 5.4 J/cm in 74 eyes (Group 1) and 42 patients treated with radiance of 7.2 J/cm in 72 eyes (Group 2). Visual acuity, subjective manifest refraction and corneal topography were analyzed before and 12 months after surgery in both groups. Postoperative complications were also noted. The results of the two protocols were statistically compared.
There were no statistically significant differences between the groups in uncorrected distance visual acuity, corrected distance visual acuity or corneal topography pre- or postoperatively. The differences in keratometric readings (K apex, SimK1 and SimK2) and refractive results were not significant.
The application of total intended UV-A radiance of 5.4 J/cm or 7.2 J/cm for accelerated CXL in patients with progressive keratoconus resulted in similar refractive and topographic outcomes.
比较不同方案用于圆锥角膜患者加速角膜胶原交联（CXL）的效果。
这项前瞻性对照研究纳入了40例患者（74只眼）接受目标紫外线A（UV-A）辐照度为5.4 J/cm²的治疗（第1组），以及42例患者（72只眼）接受辐照度为7.2 J/cm²的治疗（第2组）。在两组患者手术前及术后12个月分析视力、主观验光及角膜地形图。同时记录术后并发症。对两种方案的结果进行统计学比较。
两组患者术前及术后的裸眼远视力、矫正远视力或角膜地形图在统计学上均无显著差异。角膜曲率读数（角膜顶点K值、SimK1和SimK2）及屈光结果的差异不显著。
对于圆锥角膜患者，目标UV-A总辐照度为5.4 J/cm²或7.2 J/cm²进行加速CXL，其屈光和地形学结果相似。
