Higashihara E, Nutahara K, Niijima T
Department of Urology, Faculty of Medicine, University of Tokyo, Japan.
Urol Res. 1988;16(2):95-100. doi: 10.1007/BF00261964.
Sixteen patients with medullary sponge kidney (MSK) and renal stones underwent evaluation of calcium metabolism and acid base balance. Six normal subjects and eight patients with non-MSK absorptive hypercalciuria served as control. Nine (56%) were hypercalciuric and seven (44%) were normocalciuric (N-MSK). Hypercalciuria was divided into absorptive (AH-MSK, n = 2) and renal leak hyerpcalciuria (RH-MSK, n = 7). The mean of minimal urine pH of RH-MSK group (5.28 +/- 0.09 (SE] was significantly higher than that of normal control (4.78 +/- 0.12) and of non-MSK AH (4.80 +/- 0.6) during acute acid challenge. The mean of the arterial blood HCO3 concentration of RH-MSK group was significantly lower than that of two control groups. The urine calcium and a frequency of stone passage were decreased significantly after alkali treatment in RH-MSK.
16例髓质海绵肾（MSK）合并肾结石患者接受了钙代谢和酸碱平衡评估。6名正常受试者和8例非MSK吸收性高钙尿症患者作为对照。9例（56%）为高钙尿症，7例（44%）为正常钙尿症（N-MSK）。高钙尿症分为吸收性（AH-MSK，n = 2）和肾性漏出性高钙尿症（RH-MSK，n = 7）。在急性酸负荷试验期间，RH-MSK组的最低尿pH平均值（5.28±0.09[标准误]）显著高于正常对照组（4.78±0.12）和非MSK AH组（4.80±0.6）。RH-MSK组的动脉血HCO3浓度平均值显著低于两个对照组。RH-MSK患者经碱处理后尿钙和结石排出频率显著降低。
