Lian Xiao, Yan Bing
Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University , Siping Road 1239, Shanghai 200092, P. R. China.
Inorg Chem. 2017 Jun 19;56(12):6802-6808. doi: 10.1021/acs.inorgchem.6b03009. Epub 2017 Mar 30.
The recent discovery of lanthanide organic frameworks (Ln-MOFs) offers the potential for biomarkers or metabolites sensing. This is another field that is closely connected with life science and medicine. In this work, a stable and luminescent phosphonate Ln-MOFs MIL-91(Al:Eu) and its derivatives composite Cu@MIL-91(Al:Eu) were synthesized. The rebound of luminescence of Cu@MIL-91(Al:Eu) that origin of Eu is observed in the presence of uric acid. This On-Off-On pattern is utilized for detecting uric acid, which is the final metabolite of purine. The composite reveals excellent selectivity and sensitivity for sensing uric acid. The detection of uric acid in real urine is also investigated. The effective detection of uric acid and tentative diagnosis of hyperuricuria on the basis of test paper is demonstrated.
最近镧系有机框架材料（Ln-MOFs）的发现为生物标志物或代谢物传感提供了潜力。这是另一个与生命科学和医学密切相关的领域。在这项工作中，合成了一种稳定且发光的膦酸酯Ln-MOFs MIL-91(Al:Eu)及其衍生物复合材料Cu@MIL-91(Al:Eu)。在尿酸存在的情况下，观察到以铕为发光源的Cu@MIL-91(Al:Eu)发光的恢复。这种开-关-开模式被用于检测尿酸，尿酸是嘌呤的最终代谢产物。该复合材料在检测尿酸方面显示出优异的选择性和灵敏度。还研究了在实际尿液中检测尿酸的情况。展示了基于试纸对尿酸的有效检测及对高尿酸血症的初步诊断。
