The Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, PR China.
Nikolaev Institute of Inorganic Chemistry, Lavrentiev Avenue 3, Novosibirsk, 630090, Russia Federation.
Dalton Trans. 2020 Apr 7;49(14):4343-4351. doi: 10.1039/d0dt00175a.
A facile optical sensor for uric acid (UA), an early pathological signature for the metabolic function of humans, was developed based on water-stable coordination polymers (CPs). Herein, three new isostructural fluorescent CPs, [Ln(TCPB)(DMF)3]n (Ln = La, CP 1; Ce, CP 2 and Pr, CP 3; H3TCPB = 1,3,5-tris(1-(2-carboxyphenyl)-1H-pyrazol-3-yl)benzene), with various metal ions were solvothermally synthesized. Significantly, by regulating the metal-organic coordination interactions, the fabricated CP 3 can quantitatively recognize UA with higher sensitivity compared with CP 1 and CP 2. The mechanism for the sensing properties further demonstrates the best performance of CP 3 and the excellent selectivity for UA monitoring. This work represents the strategy of designing fluorescent CP sensors to determine UA and provides a convenient approach for developing analysis platforms for the assessment of related disease progress and human health monitoring.
一种基于水稳定性配位聚合物（CPs）的简便尿酸（UA）光学传感器，UA 是人类代谢功能的早期病理标志。本文合成了三种结构相同的荧光 CP，[Ln(TCPB)(DMF)3]n（Ln = La，CP1；Ce，CP2 和 Pr，CP3；H3TCPB = 1,3,5-三(1-(2-羧基苯基)-1H-吡唑-3-基)苯），它们是通过溶剂热法合成的，具有不同的金属离子。值得注意的是，通过调节金属-有机配位相互作用，所制备的 CP3 可以比 CP1 和 CP2 更灵敏地定量识别 UA。传感性能的机理进一步证明了 CP3 的最佳性能和对 UA 监测的优异选择性。这项工作代表了设计荧光 CP 传感器来确定 UA 的策略，并为开发相关疾病进展评估和人体健康监测的分析平台提供了一种便捷的方法。
