维生素D缺乏与糖尿病神经病变之间缺乏明确关联：对希腊和孟加拉国患者的调查
Lack of Definite Association of Vitamin D Deficiency with Diabetic Neuropathy. Investigation in Greek and in Bangladeshi Patients.
作者信息
Zambelis Thomas, Papadakis George, Kokotis Panagiotis, Villiotou Vassiliki, Dogkas Nikolaos, Karandreas Nikolaos
机构信息
Department of Neurology, National and Kapodistrian University of Athens, Aeginition Hospital, Athens, Greece
Department of Endocrinology and Diabetes, Metaxas Anticancer Hospital, Piraeus, Greece.
出版信息
In Vivo. 2017 Mar-Apr;31(2):259-261. doi: 10.21873/invivo.11054.
AIM
Determination of the 25(OH) vitamin D levels in Greek-born and in Bangladeshi immigrant patients in Greece with diabetes with and without polyneuropathy.
MATERIALS AND METHODS
The method for the detection and staging of polyneuropathy proposed by Dyck, 1988 was used.
RESULTS
A total of 111 Bangladeshi immigrants and 101 Greek diabetic patients took part in the study. Vitamin D levels were significantly lower in Bangladeshi than in Greek diabetic patients, and were significantly lower in Greek patients with small-fiber neuropathy. In Bangladeshi patients, there was no statistically significant difference in the subgroup of patients with polyneuropathy in comparison to those without polyneuropathy.
CONCLUSION
The association of vitamin D deficiency only with a small number of Greek patients with exclusively small-fiber neuropathy does not allow us to draw a definite conclusion on the role of vitamin D in the pathogenesis of diabetic neuropathy.
目的
测定希腊出生的以及希腊的孟加拉移民糖尿病患者中，伴或不伴有多发性神经病变的25(OH)维生素D水平。
材料与方法
采用1988年戴克提出的多发性神经病变检测及分期方法。
结果
共有111名孟加拉移民和101名希腊糖尿病患者参与了该研究。孟加拉糖尿病患者的维生素D水平显著低于希腊糖尿病患者，希腊小纤维神经病变患者的维生素D水平也显著更低。在孟加拉患者中，伴有多发性神经病变的患者亚组与不伴有多发性神经病变的患者亚组相比，差异无统计学意义。
结论
仅维生素D缺乏与少数仅患有小纤维神经病变的希腊患者有关，这使我们无法就维生素D在糖尿病神经病变发病机制中的作用得出明确结论。
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