Urbanski Henryk F
Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Neurobiol Aging. 2017 Jun;54:100-102. doi: 10.1016/j.neurobiolaging.2017.02.020. Epub 2017 Mar 8.
Like elderly men, old male rhesus macaques show attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate, and many of them also show reduced levels of daytime activity. It is unclear, however, if this age-associated behavioral change is causally related to the underlying decrease in circulating androgen levels. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for 6 months, designed to mimic the mean 24-hour circulating hormone patterns of young adults. Compared with the young adults, the old controls showed attenuated daytime activity levels. However, there was no difference between the androgen-supplemented old animals and the aged-matched controls, even after 6 months of treatment. The data suggest that age-associated decreases in circulating androgen levels are unlikely to be a primary reason for altered activity-rest patterns in elderly men, and that androgen supplementation paradigms might not provide any obvious therapeutic benefit.
与老年男性一样，老年雄性恒河猴的睾酮和硫酸脱氢表雄酮循环水平降低，而且它们中的许多个体白天活动水平也降低。然而，目前尚不清楚这种与年龄相关的行为变化是否与循环雄激素水平的潜在下降存在因果关系。为了验证这种可能性，给老年雄性恒河猴每日补充睾酮和脱氢表雄酮，持续6个月，旨在模拟年轻成年人平均24小时的循环激素模式。与年轻成年人相比，老年对照组的白天活动水平降低。然而，即使经过6个月的治疗，补充雄激素的老年动物与年龄匹配的对照组之间也没有差异。数据表明，循环雄激素水平与年龄相关的下降不太可能是老年男性活动-休息模式改变的主要原因，而且雄激素补充方案可能不会带来任何明显的治疗益处。
