Mohammadi Saeed, Malek Mohammadi Ashraf, Norooznezhad Amir Hossein, Heshmati Farhad, Alimoghaddam Kamran, Ghavamzadeh Ardeshir
Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Transfusion Medicine Units, Cochin Hospital, Paris, France.
Transfus Apher Sci. 2017 Jun;56(3):376-384. doi: 10.1016/j.transci.2017.01.006. Epub 2017 Feb 16.
Regardless of remarkable progresses in prevention and treatment approaches, graft versus host disease (GVHD) remains a major impediment for successful allogeneic hematopoietic stem cells transplantation (HSCT) and leads to morbidity and mortality in transplanted patients. Corticosteroids are the standard therapy for GVHD; however, a great number of patients will not respond sufficiently and others will be significantly affected by adverse effects of steroids. Extracorporeal photochemotherapy (ECP), as one of the numerous second line therapies, through modulation of immune cells may improves GVHD affected organ function in steroid-refractory forms. Considering to widespread utilization of ECP as a therapeutic strategy, we performed review on current literature of ECP, regarding the treatment strategies, monitoring protocols and technical aspects in chronic and acute GVHD.
尽管在预防和治疗方法上取得了显著进展，但移植物抗宿主病（GVHD）仍然是异基因造血干细胞移植（HSCT）成功的主要障碍，并导致移植患者发病和死亡。皮质类固醇是GVHD的标准治疗方法；然而，许多患者反应不充分，其他患者会受到类固醇不良反应的显著影响。体外光化学疗法（ECP）作为众多二线治疗方法之一，通过调节免疫细胞，可能改善类固醇难治性形式的GVHD受累器官功能。考虑到ECP作为一种治疗策略的广泛应用，我们对ECP的当前文献进行了综述，涉及慢性和急性GVHD的治疗策略、监测方案和技术方面。
