Dogan E, Dursun E, Tosun E, Bilgic E, Akman A C, Orhan K, Celik H H, Korkusuz P, Caglayan F
Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
Int J Oral Maxillofac Surg. 2017 Jul;46(7):931-937. doi: 10.1016/j.ijom.2017.03.003. Epub 2017 Mar 27.
The objective of the present study was to test the hypothesis that the addition of hyaluronic acid-based matrix to collagenated heterologous bone graft for sinus augmentation would enhance bone formation compared to collagenated heterologous bone graft alone in the early healing period, by micro-computed tomography and histomorphometry. Thirteen systemically healthy patients requiring bilateral two-stage maxillary sinus augmentation (residual crest height≤4mm) were enrolled in this split-mouth prospective randomized controlled study. One sinus side as a control group was grafted with only collagenated heterologous bone graft; the other region as a test group was grafted with hyaluronic matrix and collagenated heterologous bone graft. Bone biopsy samples were taken after 4 months during the dental implant surgery and analyzed using micro-computed tomography and histomorphometric parameters. According to the micro-computed tomography and histomorphometric results, a significantly higher percentage of new bone was observed in the test group when compared to the control group after 4 months of healing. This study confirmed the hypothesis that the addition of hyaluronic matrix to collagenated heterologous bone graft for sinus augmentation enhances bone formation compared to collagenated heterologous bone graft alone in the early healing period.
本研究的目的是通过显微计算机断层扫描和组织形态计量学，验证在早期愈合阶段，与单独使用胶原化异种骨移植相比，在胶原化异种骨移植中添加基于透明质酸的基质用于上颌窦提升是否能增强骨形成。13名需要进行双侧两阶段上颌窦提升（剩余牙槽嵴高度≤4mm）的全身健康患者参与了这项前瞻性随机对照双盲研究。一侧上颌窦作为对照组，仅植入胶原化异种骨移植；另一侧作为试验组，植入透明质酸基质和胶原化异种骨移植。在种植牙手术4个月后采集骨活检样本，并使用显微计算机断层扫描和组织形态计量学参数进行分析。根据显微计算机断层扫描和组织形态计量学结果，愈合4个月后，试验组新骨的百分比显著高于对照组。本研究证实了这一假设：在早期愈合阶段，与单独使用胶原化异种骨移植相比，在胶原化异种骨移植中添加透明质酸基质用于上颌窦提升可增强骨形成。
