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年龄在肩关节置换术的结果和并发症中的作用。

The role age plays in the outcomes and complications of shoulder arthroplasty.

机构信息

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.

Department of Biostatistics and Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

出版信息

J Shoulder Elbow Surg. 2017 Sep;26(9):1573-1580. doi: 10.1016/j.jse.2017.01.020. Epub 2017 Mar 27.

Abstract

BACKGROUND

This investigation used age as a continuous variable to estimate implant survival and the risk of complications.

METHODS

Prospectively collected data were used to analyze 5494 consecutive shoulder arthroplasties performed from 1970 to 2012. Patients were a mean age of 67 years. The association between the age at the index procedure and the risk for each outcome was assessed using Cox regression and smoothing spline analysis.

RESULTS

Older age was associated with a decreased risk of revision surgery, revision for mechanical failure, and reoperation but with a higher risk for thromboembolic events. Reoperation rates also decreased in a linear fashion with older ages (P < .001). The risk of revision surgery decreased in a linear fashion between the ages of 40 and 85, with a 3% decreased risk of revision per 1-year increase in age (P < .01). This association held true in a multivariate model and when specific procedures were separated out. Compared with patients aged <50 years, patients aged from 50 to 65 years (P < .001) and those >65 years (P < .001) have decreased risks of revision surgery. The risk of a revision surgery in a patient aged >50 years was significantly decreased (~13% reduction in risk for each year; P < .001). There was a subtle association between older age and decreased rates of infection (P = .01).

CONCLUSIONS

There is a strong association between older age and decreased rates of revision surgery and reoperation after shoulder arthroplasty, with a striking association with decreased rates of mechanical failure. These are important considerations when counseling younger patients regarding their risks.

摘要

背景

本研究采用年龄作为连续变量来评估植体生存率和并发症风险。

方法

使用前瞻性收集的数据,分析了 1970 年至 2012 年间进行的 5494 例连续肩关节置换术。患者的平均年龄为 67 岁。使用 Cox 回归和平滑样条分析评估了指数手术时的年龄与每种结局风险之间的关系。

结果

年龄较大与翻修手术、机械故障翻修和再次手术的风险降低相关,但与血栓栓塞事件的风险升高相关。随着年龄的增长,再次手术的发生率呈线性下降(P<.001)。在 40 至 85 岁之间,翻修手术的风险呈线性下降,每增加 1 岁,翻修风险降低 3%(P<.01)。这种关联在多变量模型中以及当分离出特定手术时仍然成立。与<50 岁的患者相比,50 至 65 岁(P<.001)和>65 岁(P<.001)的患者翻修手术风险降低。>50 岁患者的翻修手术风险显著降低(每年风险降低约 13%;P<.001)。年龄较大与感染率降低之间存在微妙的关联(P=.01)。

结论

在肩关节置换术后,年龄较大与翻修手术和再次手术的发生率降低之间存在很强的关联,与机械故障发生率降低之间存在显著关联。在为年轻患者提供风险咨询时,这些都是重要的考虑因素。

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