Beavers Kelsey R, Nelson Christopher E, Duvall Craig L
Interdisciplinary Graduate Program in Materials Science, Vanderbilt University, Nashville, TN 37235, USA.
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Adv Drug Deliv Rev. 2015 Jul 1;88:123-37. doi: 10.1016/j.addr.2014.12.006. Epub 2014 Dec 29.
MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networks. MiRNAs can act as master regulators of normal and pathological tissue development, homeostasis, and repair, which has motivated expanding efforts toward the development of technologies for therapeutically modulating miRNA activity for regenerative medicine and tissue engineering applications. This review highlights the tools currently available for miRNA inhibition and their recent therapeutic applications for improving tissue repair.
微小RNA(miRNA)是非编码RNA,为信使核糖核酸(mRNA)翻译成蛋白质提供内源性负反馈机制。单个miRNA可调控数百种mRNA,使miRNA能够通过同时影响多个基因网络来协调强大的生物学反应。miRNA可作为正常和病理组织发育、内环境稳定及修复的主要调节因子,这推动了人们为再生医学和组织工程应用开发治疗性调节miRNA活性技术的努力不断增加。本综述重点介绍了目前可用于抑制miRNA的工具及其在改善组织修复方面的最新治疗应用。