Liao Yulin, Flaherty Joseph H, Yue Jirong, Wang Yanyan, Deng Chuanyao, Chen Ling
Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Division of Geriatrics, Department of Internal Medicine, Saint Louis University, St Louis, Missouri, USA.
BMJ Open. 2017 Mar 29;7(3):e014726. doi: 10.1136/bmjopen-2016-014726.
Delirium is one of the most common complications after cardiac surgery in the elderly. Future studies aimed at preventing postoperative delirium will need an accurate estimate of incidence. However, there are no available systematic reviews on the incidence, and reports of incidence of postoperative delirium after a cardiac operation vary widely with significant heterogeneity. Therefore, we aim to perform a systematic review and meta-analysis to determine the most accurate incidence possible of postoperative delirium in individuals aged >65 years after cardiac surgery.
We will undertake a comprehensive literature search among PubMed, EMBASE, the Cochrane Library, PsycINFO and CINAHL, from their inception to January 2017. Prospective cohort and cross sectional studies that described the incidence of delirium will be eligible for inclusion. The primary outcome will be the incidence of delirium. Risk of bias and methodological quality for the included studies will be assessed using a risk of bias tool for prevalence studies and the Cochrane guidelines. Heterogeneity of the estimates across studies will be assessed. Incidence data will be pooled by selective or emergency surgery. This systematic review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA).
This proposed systematic review and meta-analysis is based on published data, and thus there is no requirement for ethics approval. The study will provide an up to date and accurate incidence of postoperative delirium among the older population after cardiac surgery, which is necessary for future research in this area. The findings of this study will be presented at conferences and disseminated through publication in a peer reviewed journal.
CRD42016047773.
谵妄是老年患者心脏手术后最常见的并发症之一。未来旨在预防术后谵妄的研究需要对发病率进行准确估计。然而，目前尚无关于发病率的系统评价，心脏手术后术后谵妄发病率的报告差异很大，存在显著的异质性。因此，我们旨在进行一项系统评价和荟萃分析，以确定65岁以上个体心脏手术后术后谵妄的最准确发病率。
我们将在PubMed、EMBASE、Cochrane图书馆、PsycINFO和CINAHL中进行全面的文献检索，检索时间从各数据库建库至2017年1月。描述谵妄发病率的前瞻性队列研究和横断面研究将符合纳入标准。主要结局将是谵妄的发病率。将使用患病率研究的偏倚风险工具和Cochrane指南评估纳入研究的偏倚风险和方法学质量。将评估各研究估计值的异质性。发病率数据将按择期手术或急诊手术进行汇总。本系统评价将根据系统评价和荟萃分析的首选报告项目（PRISMA）进行报告。
本拟进行的系统评价和荟萃分析基于已发表的数据，因此无需伦理批准。该研究将提供心脏手术后老年人群术后谵妄的最新且准确的发病率，这对于该领域未来的研究是必要的。本研究结果将在会议上展示，并通过在同行评审期刊上发表进行传播。
CRD42016047773。
