急性心肌梗死后行经皮冠状动脉介入治疗患者发生谵妄的发生率及危险因素：系统评价和荟萃分析方案。

Incidence and risk factors of delirium after percutaneous coronary intervention in individuals hospitalised for acute myocardial infarction: protocol for a systematic review and meta-analysis.

机构信息

Intensive Care Unit, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, China.

Department of Gastroenterology, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, China.

出版信息

BMJ Open. 2020 Dec 30;10(12):e044564. doi: 10.1136/bmjopen-2020-044564.

DOI:10.1136/bmjopen-2020-044564

PMID:33380487

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7780515/

Abstract

INTRODUCTION

Delirium in the postoperative period is a wide-reaching problem that affects important clinical outcomes. The incidence and risk factors of delirium in individuals with acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI) has not been completely determined and no relevant systematic review and meta-analysis of incidence or risk factors exists. Hence, we aim to conduct a systematic review and meta-analysis to ascertain the incidence and risk factors of delirium among AMI patients undergoing PCI.

METHODS AND ANALYSES

We will undertake a comprehensive literature search among PubMed, EMBASE, Cochrane Library, PsycINFO, CINAHL and Google Scholar from their inception to the search date. Prospective cohort and cross-sectional studies that described the incidence or at least one risk factor of delirium will be eligible for inclusion. The primary outcome will be the incidence of postoperative delirium. The quality of included studies will be assessed using a risk of bias tool for prevalence studies and the Cochrane guidelines. Heterogeneity of the estimates across studies will be assessed. Incidence and risk factors associated with delirium will be extracted. Incidence data will be pooled. Each risk factor reported in the included studies will be recorded together with its statistical significance; narrative and meta-analytical approaches will be employed. The systematic review and meta-analysis will be presented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

ETHICS AND DISSEMINATION

This proposed systematic review and meta-analysis is based on published data, and thus there is no requirement for ethics approval. The study will provide an up to date and accurate incidence and risk factors of delirium after PCI among patients with AMI, which is necessary for future research in this area. The findings of this study will be disseminated through publication in a peer-reviewed journal.

PROSPERO REGISTRATION NUMBER

CRD42020184388.

摘要

简介

术后谵妄是一个广泛存在的问题，会影响重要的临床结局。接受经皮冠状动脉介入治疗（PCI）的急性心肌梗死（AMI）患者发生谵妄的发生率和危险因素尚未完全确定，也没有关于发生率或危险因素的相关系统评价和荟萃分析。因此，我们旨在进行一项系统评价和荟萃分析，以确定接受 PCI 的 AMI 患者发生谵妄的发生率和危险因素。

方法和分析

我们将对 PubMed、EMBASE、Cochrane 图书馆、PsycINFO、CINAHL 和 Google Scholar 进行全面的文献检索，检索时间从其创建到检索日期。前瞻性队列研究和横断面研究，描述了谵妄的发生率或至少一个危险因素，将有资格入选。主要结局将是术后谵妄的发生率。将使用流行率研究的偏倚风险工具和 Cochrane 指南评估纳入研究的质量。将评估研究间估计值的异质性。将提取与谵妄相关的发生率和危险因素。将对发生率数据进行汇总。将记录纳入研究中报告的每个风险因素及其统计学意义；将采用叙述性和荟萃分析方法。将根据系统评价和荟萃分析的首选报告项目呈现系统评价和荟萃分析。