Li Siting, Yang Shiyi, Sun Xiaoning, Ma Tianxiang, Zheng Yuehong, Liu Xiao
Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005, China.
Bioengineering (Basel). 2025 Feb 17;12(2):191. doi: 10.3390/bioengineering12020191.
Intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) is associated with disease progression and complications. This study investigates the relationship between nitric oxide (NO) concentration and ILT in AAA patients using patient-specific computational fluid dynamics (CFD) models. Four AAA patients with ILT were enrolled. Patient-specific models of the aorta and branch arteries were constructed followed by CFD simulations. NO concentration was modeled based on endothelial shear stress response and its transport within the arterial lumen and wall. Hemodynamic parameters, including wall shear stress (WSS) and its derivatives, were analyzed alongside NO distribution. ILT accumulation was primarily located in the infrarenal abdominal aorta. Regions of decreased NO concentration correlated with ILT accumulated areas, whereas regions with decreased TAWSS and increased OSI were less consistent with ILT accumulation. A negative correlation was observed between the thrombus area and NO concentration, with values of less than 0.001 for four patients. The time-average area NO concentration values of lumen area with ILT were lower than those of non-ILT sections. Spatially, NO was unevenly distributed, with thicker thrombus in regions of lower NO concentration. NO distribution could serve as a better potential personalized marker for thrombosis prediction in AAA compared to WSS-derived parameters.
腹主动脉瘤（AAA）腔内血栓（ILT）与疾病进展及并发症相关。本研究使用患者特异性计算流体动力学（CFD）模型，调查AAA患者中一氧化氮（NO）浓度与ILT之间的关系。纳入了4例有ILT的AAA患者。构建了主动脉和分支动脉的患者特异性模型，随后进行CFD模拟。基于内皮剪切应力反应及其在动脉腔和壁内的传输对NO浓度进行建模。同时分析了包括壁面剪切应力（WSS）及其导数在内的血流动力学参数以及NO分布。ILT主要积聚在肾下腹主动脉。NO浓度降低的区域与ILT积聚区域相关，而TAWSS降低和OSI升高的区域与ILT积聚的一致性较差。观察到血栓面积与NO浓度之间呈负相关，4例患者的 值均小于0.001。有ILT的管腔区域的时间平均面积NO浓度值低于无ILT节段。在空间上，NO分布不均匀，NO浓度较低区域的血栓较厚。与基于WSS的参数相比，NO分布可作为更好的潜在个性化AAA血栓形成预测标志物。
