Jain Promil, Sen Rajeev, Sharma Nisha, Bhargava Shilpi, Singh Virender
Department of Pathology, Pt BDS PGIMS, University of Health Sciences, Rohtak, India.
Department of Oral Pathology, PGIDS, University of Health Sciences, Rohtak, India.
Iran J Med Sci. 2017 Mar;42(2):205-209.
Tumefactive fibroinflammatory lesions (TFLs) are rare idiopathic benign fibrosclerosing lesions that clinically simulate a malignancy. TFLs are seen more frequently in males between 10 and 74 years of age. The usual site of involvement is the head and neck region, but rarely the extremities may be involved. Coexisting fibrosclerotic processes have been reported including retroperitoneal fibrosis, sclerosing cholangitis, sclerosing mediastinal fibrosis, and orbital pseudotumors. The etiology of this poorly understood entity remains unknown. Possible suggestions include exaggerated responses or autoimmune reactions to any chronic infection. The clinical and radiological appearance of TFLs is that of malignancy, but histopathology reveals them to be a benign process broadly classified under non-neoplastic, fibroinflammatory proliferations. The treatment strategies for these lesions are not well defined and variable and include steroids, surgery, and radiotherapy either alone or in combination. TFLs, albeit not fatal, have a high recurrence rate; patients should, therefore, be kept on long-term follow-up. We describe a young female patient presenting with a rapidly developing cheek swelling, which was diagnosed histopathologically as a TFLs.
肿瘤样纤维炎性病变（TFLs）是罕见的特发性良性纤维硬化性病变，临床上类似于恶性肿瘤。TFLs在10至74岁的男性中更常见。通常受累部位是头颈部区域，但四肢很少受累。已有报道存在并存的纤维硬化性病变，包括腹膜后纤维化、硬化性胆管炎、硬化性纵隔纤维化和眼眶假瘤。这个了解甚少的实体的病因仍然不明。可能的原因包括对任何慢性感染的过度反应或自身免疫反应。TFLs的临床和放射学表现为恶性肿瘤，但组织病理学显示它们是一种良性过程，广义上归类为非肿瘤性纤维炎性增生。这些病变的治疗策略尚不明确且多样，包括单独或联合使用类固醇、手术和放疗。TFLs虽然不致命，但复发率高；因此，患者应接受长期随访。我们描述了一名年轻女性患者，表现为迅速发展的面颊肿胀，经组织病理学诊断为TFLs。
