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骨髓瘤性胸腔积液:印度南部一家三级癌症中心报告的罕见病例。

Myelomatous pleural effusion: A rare case entity reported from a tertiary care cancer center in South India.

作者信息

Babu Govind K, Saldanha Smitha C, Lokesh K N, Suresh Babu M C, Patil Akkamaha Devi, Kiran Pretesh R, Lakshmaiah K C, Lokanatha D

机构信息

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

出版信息

Lung India. 2017 Mar-Apr;34(2):176-178. doi: 10.4103/0970-2113.201318.

DOI:10.4103/0970-2113.201318
PMID:28360469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5351363/
Abstract

Multiple myeloma (MM) is a plasma cell neoplasm and constitutes 10% of hematologic malignancies. Malignant myelomatous pleural effusions are very rare and occur in <1% of cases of MM. In this article, we report a rare case of a patient who initially presented with pleural effusion and was subsequently found to be secondary to MM with an underlying raised IgG paraprotein. The patient symptomatically improved and was in partial remission with palliative radiotherapy, VTD chemotherapy, and bisphosphonates.

摘要

多发性骨髓瘤(MM)是一种浆细胞肿瘤,占血液系统恶性肿瘤的10%。恶性骨髓瘤性胸腔积液非常罕见,在MM病例中发生率<1%。在本文中,我们报告了一例罕见病例,该患者最初表现为胸腔积液,随后被发现是继发于MM,伴有潜在升高的IgG副蛋白。患者症状改善,通过姑息性放疗、VTD化疗和双膦酸盐治疗达到部分缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/9f4cceb4c920/LI-34-176-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/33d942fb9fec/LI-34-176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/556ba96cb6ac/LI-34-176-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/843fbc81b4f6/LI-34-176-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/9f4cceb4c920/LI-34-176-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/33d942fb9fec/LI-34-176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/556ba96cb6ac/LI-34-176-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/843fbc81b4f6/LI-34-176-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930a/5351363/9f4cceb4c920/LI-34-176-g004.jpg

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J Cytol. 2024 Jan-Mar;42(1):48-53. doi: 10.4103/joc.joc_87_24. Epub 2025 Feb 11.
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Case Report: A very rare case of a Pleural Effusion revealing Multiple Myeloma.病例报告:胸腔积液揭示多发性骨髓瘤,十分罕见。
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Myelomatous ascites and pleural effusion in relapsed multiple myeloma.

本文引用的文献

1
Myelomatous pleural effusion-A case report.骨髓瘤性胸腔积液——病例报告
Respir Med Case Rep. 2012;5:59-61. doi: 10.1016/j.rmedc.2011.08.003. Epub 2011 Oct 14.
2
Pulmonary and nodal multiple myeloma with a pleural effusion mimicking bronchogenic carcinoma.伴有胸腔积液的肺及淋巴结多发性骨髓瘤,酷似支气管源性癌。
J Cancer Res Ther. 2009 Oct-Dec;5(4):297-9. doi: 10.4103/0973-1482.59915.
3
Plasma cell myeloma presenting with diffuse pleural involvement: a hitherto unreported pattern of a new mesothelioma mimicker.浆细胞骨髓瘤伴弥漫性胸膜受累:一种新的间皮瘤模拟物的迄今未报道的模式。
复发多发性骨髓瘤中的骨髓瘤性腹水和胸腔积液
Clin Case Rep. 2022 Feb 2;10(2):e05329. doi: 10.1002/ccr3.5329. eCollection 2022 Feb.
Ann Diagn Pathol. 2010 Feb;14(1):30-5. doi: 10.1016/j.anndiagpath.2009.10.005.
4
Refractory plasmablastic type myeloma with multiple extramedullary plasmacytomas and massive myelomatous effusion: remarkable response with a combination of thalidomide and dexamethasone.伴有多发髓外浆细胞瘤和大量骨髓瘤性积液的难治性浆母细胞型骨髓瘤:沙利度胺与地塞米松联合治疗取得显著疗效
Intern Med. 2009;48(20):1827-32. doi: 10.2169/internalmedicine.48.2142. Epub 2009 Oct 15.
5
Multiple myeloma presenting initially with pleural effusion and a unique paraspinal tumor in the thorax.多发性骨髓瘤最初表现为胸腔积液和胸部独特的椎旁肿瘤。
Intern Med. 2008;47(21):1917-20. doi: 10.2169/internalmedicine.47.1296. Epub 2008 Nov 4.
6
Unsuspected multiples myeloma presenting as bilateral pleural effusion - a cytological diagnosis.以双侧胸腔积液为表现的隐匿性多发性骨髓瘤——细胞学诊断
Cytojournal. 2007 Sep 7;4:17. doi: 10.1186/1742-6413-4-17.
7
Myelomatous pleural effusion.骨髓瘤性胸腔积液
J Assoc Physicians India. 2005 Aug;53:734-6.
8
Malignant pleural effusion of multiple myeloma: prognostic factors and outcome.多发性骨髓瘤的恶性胸腔积液:预后因素与结局
Leuk Lymphoma. 2005 Aug;46(8):1137-42. doi: 10.1080/10428190500102845.
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Multiple myeloma presenting initially as a solitary pleural effusion later complicated by malignant plasmacytic ascites.多发性骨髓瘤最初表现为孤立性胸腔积液,后来并发恶性浆细胞性腹水。
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