Chen Danlei, Zhang Fengyun, Ren Haifeng, Luo Jia, Wang Siying
School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Department of Pharmacology and Nutritional Sciences, University of Kentucky, College of Medicine, Lexington, KY, USA.
Onco Targets Ther. 2017 Mar 17;10:1665-1671. doi: 10.2147/OTT.S129781. eCollection 2017.
Excessive chronic alcohol consumption has become a worldwide health problem. The oncogenic effect of chronic alcohol consumption is one of the leading concerns. The mechanisms of alcohol-induced tumorigenesis and tumor progression are largely unknown, although many factors have been implicated in the process. This review discusses the recent progress in this research area with concentration on alcohol-induced dysregulation of cytokines and chemokines. Based on the available evidence, we propose that alcohol promotes tumor progression by the dysregulation of the cytokine/chemokine system. In addition, we discuss specific transcription factors and signaling pathways that are involved in the action of these cytokines/chemokines and the oncogenic effect of alcohol. This review provides novel insight into the mechanisms of alcohol-induced tumor promotion.
长期过量饮酒已成为一个全球性的健康问题。长期饮酒的致癌作用是主要关注点之一。尽管在此过程中有许多因素被牵涉其中，但酒精诱导肿瘤发生和肿瘤进展的机制在很大程度上仍不清楚。本综述讨论了该研究领域的最新进展，重点关注酒精诱导的细胞因子和趋化因子失调。基于现有证据，我们提出酒精通过细胞因子/趋化因子系统的失调促进肿瘤进展。此外，我们还讨论了参与这些细胞因子/趋化因子作用及酒精致癌效应的特定转录因子和信号通路。本综述为酒精诱导肿瘤促进的机制提供了新的见解。
