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QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone.抗精神病药物利培酮的QT间期延长主要与其9-羟基代谢物帕利哌酮有关。
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Hemopericardium and cardiac tamponade in a patient with an elevated international normalized ratio.国际标准化比值升高患者的血心包和心脏压塞。
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Clozapine-induced cardiotoxicity: a clinical update.氯氮平所致心脏毒性：临床最新进展
Med J Aust. 2009 Feb 16;190(4):190-2. doi: 10.5694/j.1326-5377.2009.tb02345.x.
5
Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study.帕利哌酮缓释片（帕利哌酮ER）的疗效、安全性及早期反应：一项为期6周的随机、安慰剂对照研究结果
Schizophr Res. 2007 Jul;93(1-3):117-30. doi: 10.1016/j.schres.2007.03.003. Epub 2007 Apr 26.
6
Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?新型抗抑郁药和抗精神病药的心血管副作用：新药，旧担忧？
Curr Pharm Des. 2004;10(20):2463-75. doi: 10.2174/1381612043383872.
7
Clozapine and sudden death.氯氮平与猝死
Lancet. 2000 Mar 4;355(9206):841; author reply 843. doi: 10.1016/s0140-6736(00)00035-0.
8
Myocarditis and cardiomyopathy associated with clozapine.与氯氮平相关的心肌炎和心肌病。
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帕利哌酮：作为心包积液的一个可能病因

Paliperidone: As a Possible Cause of Pericardial Effusion.

作者信息

Şahpolat Musa, Küçükdurmaz Zekeriya, Kavakçi Önder, Kurt Recep

机构信息

Department of Psychiatry, Cumhuriyet University Faculty of Medicine Hospital, Sivas, Turkey.

Department of Cardiology, Cumhuriyet University Faculty of Medicine Hospital, Sivas Sivas, Turkey.

出版信息

Noro Psikiyatr Ars. 2014 Jun;51(2):169-171. doi: 10.4274/npa.y7061. Epub 2014 Jun 1.

DOI:10.4274/npa.y7061
PMID:28360618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5353093/
Abstract

Paliperidone which is the active metabolite of risperidon is one of the novel antipsychotics. Controlled clinical studies proved its effectiveness on decreasing the positive and negative symptoms of schizophrenia. Some studies and case reports, reported its cardiovascular and cardiometabolic side effects. Cardiac tamponade, that may be mortal, wasn't reported as a side effect with paliperidone usage before. We present a 40 years old female with catatonic schizophrenia for eighteen years, whom was on 6 mg/day paliperidon for 3 years and presented with pericardial tamponade. We suggest that paliperdione may have cardiovascular and cardiometabolic side effects also in therapeutic doses.

摘要

帕利哌酮是利培酮的活性代谢产物，属于新型抗精神病药物。对照临床研究证实其对减轻精神分裂症的阳性和阴性症状有效。一些研究和病例报告指出了其心血管和心脏代谢方面的副作用。此前未报告过使用帕利哌酮会导致可能致命的心脏压塞这一副作用。我们报告一例40岁女性，患紧张型精神分裂症18年，服用帕利哌酮6毫克/天，共3年，出现了心包压塞。我们认为帕利哌酮在治疗剂量下也可能产生心血管和心脏代谢方面的副作用。