酵母中染色体的稳定性。
The stability of chromosomes in yeast.
作者信息
Larionov V L, Karpova T S, Zhouravleva G A, Pashina O B, Nikolaishvili N T, Kouprina N Y
机构信息
Institute of Cytology, Academy of Sciences of the USSR, Leningrad.
出版信息
Curr Genet. 1987;11(6-7):435-43. doi: 10.1007/BF00384604.
CL mutants with high instability of chromosome III were UV-induced in haploid strain disomic for chromosome III. The obtained CL mutants can be divided into two groups: (1) CL2, CL3, CL7, CL11-CL13 with elevated level of spontaneous inter- and intragenic recombination and (2) CL4, CL8 in which instability of chromosome III is not accompanied by elevation of mitotic recombination frequency. CL4 and CL8 mutants also show unstable maintenance of artificial minichromosomes with different chromosomal replicators and centromeric loci. The instability of chromosome III and minichromosomes in CL4 and CL8 is determined by two nonallelic genes designated ch14 and ch18. The role of ch14 and ch18 genes in mitotic chromosome transmission is discussed.
在对第三条染色体二体的单倍体菌株中，通过紫外线诱导得到了第三条染色体具有高不稳定性的CL突变体。所获得的CL突变体可分为两组：（1）CL2、CL3、CL7、CL11 - CL13，其自发基因间和基因内重组水平升高；（2）CL4、CL8，其中第三条染色体的不稳定性并不伴随着有丝分裂重组频率的升高。CL4和CL8突变体还表现出具有不同染色体复制子和着丝粒位点的人工微型染色体的不稳定维持。CL4和CL8中第三条染色体和微型染色体的不稳定性由两个非等位基因ch14和ch18决定。讨论了ch14和ch18基因在有丝分裂染色体传递中的作用。
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