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昼夜节律影响脉冲电磁场对大鼠坐骨神经再生的促进作用。

Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats.

作者信息

Zhu Shu, Ge Jun, Liu Zhongyang, Liu Liang, Jing Da, Ran Mingzi, Wang Meng, Huang Liangliang, Yang Yafeng, Huang Jinghui, Luo Zhuojing

机构信息

Institute of Orthopaedics, Xijing Hospital, The Fourth Military Medical University , Xi'an , China.

Department of Orthopaedics, 323rd Hospital of PLA, Xi'an, China; Department of Anatomy, The Fourth Military Medical University, Xi'an, China.

出版信息

Front Neurol. 2017 Mar 15;8:101. doi: 10.3389/fneur.2017.00101. eCollection 2017.

DOI:10.3389/fneur.2017.00101
PMID:28360885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5350136/
Abstract

Circadian rhythm (CR) plays a critical role in the treatment of several diseases. However, the role of CR in the treatment of peripheral nerve defects has not been studied. It is also known that the pulsed electromagnetic fields (PEMF) can provide a beneficial microenvironment to quicken the process of nerve regeneration and to enhance the quality of reconstruction. In this study, we evaluate the impact of CR on the promoting effect of PEMF on peripheral nerve regeneration in rats. We used the self-made "collagen-chitosan" nerve conduits to bridge the 15-mm nerve gaps in Sprague-Dawley rats. Our results show that PEMF stimulation at daytime (DPEMF) has most effective outcome on nerve regeneration and rats with DPEMF treatment achieve quickly functional recovery after 12 weeks. These findings indicate that CR is an important factor that determines the promoting effect of PEMF on peripheral nerve regeneration. PEMF exposure in the daytime enhances the functional recovery of rats. Our study provides a helpful guideline for the effective use of PEMF mediations experimentally and clinically.

摘要

昼夜节律（CR）在多种疾病的治疗中起着关键作用。然而，CR在周围神经缺损治疗中的作用尚未得到研究。众所周知，脉冲电磁场（PEMF）可以提供有益的微环境，以加速神经再生过程并提高重建质量。在本研究中，我们评估了CR对PEMF促进大鼠周围神经再生作用的影响。我们使用自制的“胶原蛋白-壳聚糖”神经导管来桥接Sprague-Dawley大鼠15毫米的神经缺损。我们的结果表明，白天进行PEMF刺激（DPEMF）对神经再生最有效，接受DPEMF治疗的大鼠在12周后能快速实现功能恢复。这些发现表明，CR是决定PEMF对周围神经再生促进作用的重要因素。白天暴露于PEMF可增强大鼠的功能恢复。我们的研究为在实验和临床中有效使用PEMF介导提供了有益的指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/0a57f0a2c912/fneur-08-00101-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/49c1ad6ffe95/fneur-08-00101-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/e7d57a253f54/fneur-08-00101-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/27687f4e3723/fneur-08-00101-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/6c1a3726b424/fneur-08-00101-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/f9bc071203e2/fneur-08-00101-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/09b1575016f7/fneur-08-00101-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/21c95348209b/fneur-08-00101-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/3046dc698e5b/fneur-08-00101-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/0a57f0a2c912/fneur-08-00101-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/49c1ad6ffe95/fneur-08-00101-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/e7d57a253f54/fneur-08-00101-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/27687f4e3723/fneur-08-00101-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/6c1a3726b424/fneur-08-00101-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/f9bc071203e2/fneur-08-00101-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/09b1575016f7/fneur-08-00101-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/21c95348209b/fneur-08-00101-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/3046dc698e5b/fneur-08-00101-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f482/5350136/0a57f0a2c912/fneur-08-00101-g009.jpg

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