Jackson-Grusby L L, Pravtcheva D, Ruddle F H, Linzer D I
Department of Biochemistry, Northwestern University, Evanston, Illinois 60208.
Endocrinology. 1988 Jun;122(6):2462-6. doi: 10.1210/endo-122-6-2462.
The chromosomal assignments of genes in the PRL/GH family in the mouse have been determine in mouse-hamster hybrid cell lines. Mouse GH (mGH) appears to be encoded by a single copy gene located on chromosome 11 and is part of a highly conserved region between mouse chromosome 11 and human chromosome 17. All of the other genes in this hormone family, including those encoding mPRL, mouse placental lactogens I and II, and mouse proliferin and proliferin-related protein, map to chromosome 13.
已在小鼠 - 仓鼠杂交细胞系中确定了小鼠PRL/GH家族中基因的染色体定位。小鼠生长激素(mGH)似乎由位于11号染色体上的单拷贝基因编码,并且是小鼠11号染色体和人类17号染色体之间高度保守区域的一部分。该激素家族中的所有其他基因,包括编码mPRL、小鼠胎盘催乳素I和II以及小鼠增殖蛋白和增殖蛋白相关蛋白的基因,都定位于13号染色体。