Owerbach D, Rutter W J, Cooke N E, Martial J A, Shows T B
Science. 1981 May 15;212(4496):815-6. doi: 10.1126/science.7221563.
The gene for prolactin has been located on chromosome 6 in humans. DNA fragments of 4.8 and 4.0 kilobases containing prolactin gene sequences were identified in human genomic DNA, whereas DNA fragments of 7.4, 3.6, and 3.3 kilobases containing prolactin gene sequences were found in mouse cells. In somatic cell hybrids of human and mouse cells the 7.4-, 3.6-, and 3.3-kilobase mouse fragments were always present, whereas the 4.8- and 4.0-kilobase human fragments were only present when human chromosome 6 was also present. We conclude that the prolactin gene resides on chromosome 6, a different location from those of the genes for the related hormones chorionic somatomammotropin and growth hormone.
催乳素基因已定位在人类的6号染色体上。在人类基因组DNA中鉴定出了含有催乳素基因序列的4.8千碱基和4.0千碱基的DNA片段，而在小鼠细胞中发现了含有催乳素基因序列的7.4千碱基、3.6千碱基和3.3千碱基的DNA片段。在人和小鼠细胞的体细胞杂种中，总是存在7.4千碱基、3.6千碱基和3.3千碱基的小鼠片段，而只有当人类6号染色体也存在时，才会出现4.8千碱基和4.0千碱基的人类片段。我们得出结论，催乳素基因位于6号染色体上，与相关激素绒毛膜促生长催乳素和生长激素的基因位置不同。
