College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
J Org Chem. 2017 Apr 21;82(8):4444-4448. doi: 10.1021/acs.joc.7b00343. Epub 2017 Apr 10.
An efficient catalyst-, base-, and oxidant-free direct cyanoalkylarylation of isocyanides with AIBN has been developed under mild conditions. This strategy provides an elusive and rapid access to a wide range of cyano-containing phenanthridine derivatives in good yields via a one-pot alkylation/cyclization radical-cascade process. The mild reaction conditions together with no need of any catalyst, base, or oxidant make this protocol environmentally benign and practical.
在温和条件下，AIBN 实现了高效的无催化剂、无碱和无氧化剂的异氰基与芳基腈的直接氰烷基化。该策略通过一锅烷基化/环化自由基级联过程，以良好的收率提供了一种难以实现的快速合成广泛的含氰基菲啶衍生物的方法。温和的反应条件以及无需任何催化剂、碱或氧化剂使得该方案具有环境友好和实用的特点。
