State Key Laboratory of Analytical Chemistry for Life Science and Institute of Chemical Biology and Drug Innovation, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210093, China.
Org Lett. 2014 Jun 6;16(11):2938-41. doi: 10.1021/ol501081h. Epub 2014 May 21.
A practical and unified strategy has been described for the preparation of mono- and difluoromethylated phenanthridine derivatives using a visible-light-promoted alkylation and decarboxylation sequence from biphenyl isocyanides with ethyl bromofluoroacetate (EBFA) or ethyl bromodifluoroacetate (EBDFA). These reactions could be carried out at room temperature in good to excellent chemical yields. Both stepwise and one-pot procedures have been developed, which makes this strategy more attractive.
已经描述了一种实用且统一的策略，用于通过使用联苯异氰化物与溴氟乙酸乙酯（EBFA）或溴二氟乙酸乙酯（EBDFA）的可见光促进的烷基化和脱羧序列来制备单和二氟甲基化菲啶衍生物。这些反应可以在室温下以良好到优异的化学收率进行。已经开发了分步和一锅法，这使得该策略更具吸引力。
