Rasti Sima, Hassanzadeh Malihe, Hooshyar Hossein, Momen-Heravi Mansooreh, Mousavi Seyed Gholam Abbas, Abdoli Amir
a Department of Parasitology and Mycology, Faculty of Medicine , Kashan University of Medical Sciences , Kashan , Iran.
b Department of Infectious Disease, Faculty of Medicine , Kashan University of Medical Sciences , Kashan , Iran.
Scand J Gastroenterol. 2017 Jun-Jul;52(6-7):738-741. doi: 10.1080/00365521.2017.1308547. Epub 2017 Mar 31.
Intestinal parasitic infections (IPIs) are important causes of morbidity and mortality in patients with immunocompromising conditions.
The aim of this study was to determine the prevalence of IPIs in different groups of immunocompromised patients, including hemodialysis patients (HD), renal transplant recipients (RTR), cancer and HIV/AIDS patients in comparison with healthy individuals in two central cities of Iran (Kashan and Qom).
In this case-control study, the stool samples of 135 HD, 50 RTR, 60 cancer patients, 20 HIV/AIDS patients and 120 healthy subjects were tested using direct-smear, formol-ether concentration, Ziehl-Neelsen staining and Agar plate method.
The overall infection rate was 11.7% (31/265) in patient groups and 0% (0/120) in the control group. The frequency of parasites was 25% in HIV/AIDS patients, 11.9% (16/135) in HD, 12.0% (6/50) in RTR and 6.7% (4/60) in cancer patients. Blastocystis hominis (4.2%) and Giardia lamblia (3.0%) were the most prevalent parasites in patient groups. The infection rate was significantly higher in male (17.6%) than female (5.4%) patients (p = .002), but no statistically significant association was observed according to the age and educational levels.
This study showed a high prevalence of IPIs in immunocompromised patients. The results of this study suggest that periodic stool examinations for screening of IPIs should be included as a part of routine medical care in these patients.
肠道寄生虫感染（IPIs）是免疫功能低下患者发病和死亡的重要原因。
本研究旨在确定伊朗两个中心城市（卡尚和库姆）不同免疫功能低下患者群体（包括血液透析患者（HD）、肾移植受者（RTR）、癌症患者和艾滋病毒/艾滋病患者）中肠道寄生虫感染的患病率，并与健康个体进行比较。
在这项病例对照研究中，使用直接涂片法、甲醛乙醚浓缩法、齐-尼氏染色法和琼脂平板法对135名血液透析患者、50名肾移植受者、60名癌症患者、20名艾滋病毒/艾滋病患者和120名健康受试者的粪便样本进行检测。
患者组的总体感染率为11.7%（31/265），对照组为0%（0/120）。艾滋病毒/艾滋病患者的寄生虫感染率为25%，血液透析患者为11.9%（16/135），肾移植受者为12.0%（6/50），癌症患者为6.7%（4/60）。人芽囊原虫（4.2%）和蓝氏贾第鞭毛虫（3.0%）是患者组中最常见的寄生虫。男性患者的感染率（17.6%）显著高于女性患者（5.4%）（p = 0.002），但根据年龄和教育水平未观察到统计学上的显著关联。
本研究表明免疫功能低下患者中肠道寄生虫感染的患病率较高。本研究结果表明，应将定期粪便检查以筛查肠道寄生虫感染作为这些患者常规医疗护理的一部分。
