Yang Jianzhou, Wang Haili, Ji Aifang, Ma Liang, Wang Jinsheng, Lian Changhong, Wei Zibai, Wang Lidong
a School of Public Health, Central South University , Changsha , Hunan , China.
b Department of Preventive Medicine , Changzhi Medical College , Changzhi , China.
Nutr Cancer. 2017 May-Jun;69(4):593-600. doi: 10.1080/01635581.2017.1299873. Epub 2017 Mar 31.
Experimental studies have determined the chemopreventive effects of vitamin D against the esophageal squamous cell carcinoma (ESCC); however, results from the epidemiological studies are not yet well established. The current study aimed to evaluate the associations between plasma vitamin D levels and variants on vitamin D metabolic-related genes with the risks for ESCC. A hospital-based case-control study was performed. Five hundred eighty-two ESCC patients and 569 controls were recruited in a Northern Chinese population. Common variants on vitamin D metabolism-related genes CYP24A1, DHCR7, GC, CYP27B1, and vitamin D receptor (VDR) and the plasma 25(OH)D level were determined. The unconditional logistic regression method was applied to determine the associations between the variants and vitamin D level and ESCC. Higher plasma 25(OH)D was associated with a reduced risk for ESCC, especially for rs2296241, rs11568820, and rs4646536. The variants rs2296241 on CYP24A1 and rs11568820 on VDR are significantly associated with ESCC cancer. Vitamin D signaling pathways may participate in the ESCC development. Further studies with larger sample size are warranted to confirm the results. Intervention studies are needed to determine whether vitamin D supplementation may reduce the ESCC risk in the Chinese population.
实验研究已确定维生素D对食管鳞状细胞癌（ESCC）具有化学预防作用；然而，流行病学研究的结果尚未完全确立。本研究旨在评估血浆维生素D水平以及维生素D代谢相关基因的变异与ESCC风险之间的关联。开展了一项基于医院的病例对照研究。在中国北方人群中招募了582例ESCC患者和569名对照。测定了维生素D代谢相关基因CYP24A1、DHCR7、GC、CYP27B1和维生素D受体（VDR）的常见变异以及血浆25(OH)D水平。应用无条件逻辑回归方法来确定这些变异、维生素D水平与ESCC之间的关联。较高的血浆25(OH)D与ESCC风险降低相关，尤其是对于rs2296241、rs11568820和rs4646536。CYP24A1上的rs2296241变异和VDR上的rs11568820变异与ESCC显著相关。维生素D信号通路可能参与ESCC的发生发展。需要进一步开展更大样本量的研究来证实这些结果。需要进行干预研究以确定补充维生素D是否可降低中国人群的ESCC风险。
