Thawani Jayesh P, Singh Nickpreet, Pisapia Jared M, Abdullah Kalil G, Parker Drew, Pukenas Bryan A, Zager Eric L, Verma Ragini, Brem Steven
Department of Neurosurgery, Univer-sity of Pennsylvania, Philadelphia, Pennsylvania.
School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.
Neurosurgery. 2017 Apr 1;80(4):635-645. doi: 10.1093/neuros/nyx009.
Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain.
To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy.
Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques.
This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution.
Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.
弥漫性低级别胶质瘤（DLGGs）代表几种浸润和侵犯脑皮质及皮质下结构的病理实体。
描述DLGGs快速成型及手术相关解剖结构的方法。
利用高清成像数据和快速成型技术，我们能够生成3例患者的DLGGs模型，并使用先进的扩散张量成像技术在三维空间中呈现相关的白质束。
本报告展示了三维（3-D）打印在神经外科的新应用，以及一种针对皮质下白质束解剖结构在三维空间中对个体化肿瘤进行建模的方法。在我们机构，教员和住院医师对该技术的评价良好。
了解个体内存在的解剖关系是成功进行神经外科治疗的基础。基于成像的快速成型可能会提高我们规划和治疗复杂神经肿瘤病理学的能力。
