Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia.
Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11000 Belgrade, Serbia.
Carbohydr Polym. 2017 Jun 1;165:313-321. doi: 10.1016/j.carbpol.2017.02.064. Epub 2017 Feb 20.
New bioactive and antimicrobial biomaterials were produced by alginate-mediated biomineralization with Zn-mineral phase. The synthesis procedure is simple, cost-effective and resulted in two different Zn-mineralized alginate nanocomposites, Zn-carbonate/Zn-alginate and Zn-phosphate/Zn-alginate. The presence of Zn-mineral phase and its type, have significantly affected nanocomposite morphology, stability, total metallic loading and potential to release Zn(II) in physiological environment. Antimicrobial experiments showed that both types of Zn-mineralized nanocomposites exhibit strong antimicrobial effect against Escherichia coli, Staphylococcus aureus and Candida albicans. These results suggest that alginate biomineralization, where minerals are salts of essential metallic ions like Zn(II), represents a good strategy for designing multifunctional biomaterials for potential biomedical applications.
通过与 Zn 矿相的藻酸盐介导的生物矿化作用，制备了具有新的生物活性和抗菌性能的生物材料。该合成方法简单、经济高效，得到了两种不同的 Zn 矿化藻酸盐纳米复合材料，即 Zn 碳酸盐/Zn 藻酸盐和 Zn 磷酸盐/Zn 藻酸盐。Zn 矿相的存在及其类型显著影响了纳米复合材料的形态、稳定性、总金属负载和在生理环境中释放 Zn(II)的能力。抗菌实验表明，两种类型的 Zn 矿化纳米复合材料均对大肠杆菌、金黄色葡萄球菌和白色念珠菌表现出强烈的抗菌作用。这些结果表明，藻酸盐生物矿化作用，其中矿物质是 Zn(II)等必需金属离子的盐，为设计潜在的用于生物医学应用的多功能生物材料提供了一种很好的策略。
