Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
Eur J Pharm Sci. 2017 Jun 15;104:72-81. doi: 10.1016/j.ejps.2017.03.031. Epub 2017 Mar 30.
Tablet coating is a common unit operation in the pharmaceutical industry. To improve currently established processes, it is important to understand the influence of the process parameters on the coating quality. One of the critical parameters is the tablet velocity. In this work, numerical results are compared to results obtained experimentally. Tablet movement in the drums was simulated using the Discrete Element Method (DEM). The simulation parameters were adapted to fit the simulation to the experimental data. A comparison of the experimental and simulation results showed that the simulation correctly represents the real tablet velocity. A change in the velocity over time and its dependence on the rotation rates and the baffle position in the simulation were similar to the experimental results. In summary, simulations can improve the understanding of tablet coating processes and will thus provide insights into the underlying process mechanics, which cannot be obtained via ordinary experiments.
片剂包衣是制药行业中的常见单元操作。为了改进现有的工艺，了解工艺参数对包衣质量的影响非常重要。其中一个关键参数是片剂速度。在这项工作中，数值结果与实验结果进行了比较。使用离散元法（DEM）模拟了鼓内片剂的运动。模拟参数经过调整以适应模拟与实验数据的拟合。实验和模拟结果的比较表明，模拟正确地表示了实际的片剂速度。随着时间的推移速度的变化及其对模拟中旋转速度和挡板位置的依赖性与实验结果相似。总之，模拟可以提高对片剂包衣过程的理解，并为深入了解基本的过程力学提供依据，而这些无法通过普通实验获得。
