从海洋来源的链霉菌属中分离出的两种新化合物

Two new compounds from a marine-derived Streptomyces sp.

作者信息

Zhou Si-Yu, Zou Yan-Lin, Wang Guo-Wei, Liao Zhi-Hua, Chen Min

机构信息

a Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), College of Pharmaceutical Sciences, Ministry of Education , Southwest University , Chongqing 400715 , China.

b School of Life Sciences , Southwest University , Chongqing 400715 , China.

出版信息

J Asian Nat Prod Res. 2017 Dec;19(12):1172-1176. doi: 10.1080/10286020.2017.1307189. Epub 2017 Apr 1.

DOI:10.1080/10286020.2017.1307189

PMID:28366016

Abstract

Two new long-chain unsaturated compounds, (2E, 6E)-10-methoxy-3,7-dimethyl-10-oxodeca-2,6-dienoic acid (1) and (2E, 6E)-3,7,11-trimethyldodeca-2,6-dienedioic acid (2), together with seven known compounds were isolated from a marine-derived Streptomyces sp. Their structures were determined by spectroscopic methods, including 2D NMR techniques. Compounds 1 and 2 were investigated for their antibacterial activities.

摘要

从一株海洋来源的链霉菌中分离出两种新的长链不饱和化合物，即(2E, 6E)-10-甲氧基-3,7-二甲基-10-氧代-2,6-癸二烯酸（1）和(2E, 6E)-3,7,11-三甲基十二烷-2,6-二烯二酸（2），以及七种已知化合物。它们的结构通过光谱方法确定，包括二维核磁共振技术。对化合物1和2进行了抗菌活性研究。