裂孢菌素 A 和 B：海洋放线菌链霉菌 NA02069 的两种新生物碱。
Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069.
机构信息
State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Key Laboratory of Biology and Genetic Resources of Tropical Crops of Ministry of Agriculture, Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
出版信息
Mar Drugs. 2017 Aug 2;15(8):244. doi: 10.3390/md15080244.
Two new alkaloids, strepchazolins A () and B (), together with a previously reported compound, streptazolin (), were isolated from a marine actinomycete, NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher's method. Compound showed weak anti- activity with the MIC value of 64.0 μM, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC value of 50.6 μM, while its diastereoisomer, Compound , is almost inactive.
从中国海南岛海域采集的海洋放线菌 NA02069 中分离得到两个新的生物碱，strepchazolins A () 和 B ()，以及一个先前报道的化合物 streptazolin ()。新化合物的结构通过广泛的 NMR、质谱和 X 射线晶体学分析以及改良的 Mosher 法确定。化合物 表现出较弱的抗活性，MIC 值为 64.0 μM，对体外乙酰胆碱酯酶 (AChE) 的抑制活性较弱，IC 值为 50.6 μM，而其非对映异构体化合物 则几乎没有活性。
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